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Study · In vitro (cells) · 2014

2 results

The study of cellular cytotoxicity of argireline - an anti-aging peptide.

Grosicki M, Latacz G, Szopa A, Cukier A, Kieć-Kononowicz K

Acta biochimica Polonica17 Mar 2014Cited by 17 (Europe PMC)

PMID24644551 (opens in a new tab)DOI10.18388/abp.2014_1919 (opens in a new tab)PepBankPUB-24644551
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human cell cultures, argireline produced dose-dependent antiproliferative effects.

    In plain wordsIn cells, argireline reduced proliferation in a dose-dependent manner.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    DecreaseCell proliferation
    Study

    humann: not reported in source

    HEK-293, IMR-32 and primary skin fibroblasts
    Outcome group
    Adverse events · Whole body
    Studied dose
    Several concentrationsAs given in this study (human).

    Source sentences

    Summary
    In conclusion, the considered method resulted in dose-dependent argireline anti-proliferation effects.
    2 context sentences
    Summary · context
    The influence of argireline on cellular proliferation was examined against: human embryonic kidney HEK-293 cell line, human neuroblastoma IMR-32 cell line, and human primary skin fibroblasts.
    Summary · context
    Tests were performed using formazan-based cell proliferation assay: EZ4U, which allows to measure the efficiency of mitochondrial oxidative activity in living cells.
  2. 02LabIn vitro (cells)Safety outcome

    In human cell cultures, significant argireline cytotoxicity required concentrations 18 to 10 000 fold higher than doxorubicin, depending on cell type.

    In plain wordsIn cells, argireline required 18 to 10 000 fold higher concentrations than doxorubicin for significant toxicity, depending on cell type.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseConcentration required for significant cytotoxicity
    Study

    humann: not reported in source

    HEK-293, IMR-32 and primary skin fibroblasts
    Comparator
    Doxorubicin
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Measurements

    Cytotoxic concentration ratio
    18 to 10,000 fold
    argireline versus doxorubicin, depending on cells

    Source sentences

    Summary
    However, the significant cytotoxicity of argireline solution was observed under 18 to 10 000 fold higher concentrations (depending on cells that were examined) in comparison to doxorubicin.
    2 context sentences
    Summary · context
    The influence of argireline on cellular proliferation was examined against: human embryonic kidney HEK-293 cell line, human neuroblastoma IMR-32 cell line, and human primary skin fibroblasts.
    Summary · context
    Tests were performed using formazan-based cell proliferation assay: EZ4U, which allows to measure the efficiency of mitochondrial oxidative activity in living cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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