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Study · Randomized controlled trial · n = 27 · 2014

4 results

Oxytocin-augmented social cognitive skills training in schizophrenia.

Davis MC, Green MF, Lee J, Horan WP, Senturk D, Clarke AD, Marder SR

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology18 Mar 2014Cited by 102 (Europe PMC)

PMID24637803 (opens in a new tab)PMCIDPMC4104336 (opens in a new tab)DOI10.1038/npp.2014.68 (opens in a new tab)PepBankPUB-24637803
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male outpatients with schizophrenia, intranasal oxytocin before social cognitive training produced greater improvement in empathic accuracy than placebo, after training and at 1 month.

    In plain wordsIn men with schizophrenia, oxytocin before social skills training improved empathic accuracy more than placebo, after training and one month later.

    Peptide
    Oxytocin
    Outcome
    IncreaseEmpathic accuracy
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · 6 weeks (12 sessions)As given in this study (human).

    Source sentences

    Summary
    Subjects receiving OT demonstrated significantly greater improvements in empathic accuracy than those receiving placebo at both posttreatment and 1 month follow up.
    2 context sentences
    Summary · context
    Twenty seven male outpatients with schizophrenia participated in a 6-week (12 session) training on social cognitive skills.
    Summary · context
    Subjects were randomly assigned (double blind) to receive either intranasal OTor placebo 30 min before each session.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male outpatients with schizophrenia, oxytocin had no effect on the other social cognitive tests versus placebo.

    In plain wordsIn men with schizophrenia, oxytocin did not change the other social thinking tests compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeOther social cognitive tests
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · 6 weeks (12 sessions)As given in this study (human).

    Source sentences

    Summary
    There were no OT-related effects for the other social cognitive tests, clinical symptoms, or neurocognition.
    2 context sentences
    Summary · context
    Twenty seven male outpatients with schizophrenia participated in a 6-week (12 session) training on social cognitive skills.
    Summary · context
    Subjects were randomly assigned (double blind) to receive either intranasal OTor placebo 30 min before each session.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In male outpatients with schizophrenia, oxytocin had no effect on clinical symptoms versus placebo.

    In plain wordsIn men with schizophrenia, oxytocin did not change clinical symptoms compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeClinical symptoms
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 6 weeks (12 sessions)As given in this study (human).

    Source sentences

    Summary
    There were no OT-related effects for the other social cognitive tests, clinical symptoms, or neurocognition.
    2 context sentences
    Summary · context
    Twenty seven male outpatients with schizophrenia participated in a 6-week (12 session) training on social cognitive skills.
    Summary · context
    Subjects were randomly assigned (double blind) to receive either intranasal OTor placebo 30 min before each session.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In male outpatients with schizophrenia, oxytocin had no effect on neurocognition versus placebo.

    In plain wordsIn men with schizophrenia, oxytocin did not change general thinking performance compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeNeurocognition
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · 6 weeks (12 sessions)As given in this study (human).

    Source sentences

    Summary
    There were no OT-related effects for the other social cognitive tests, clinical symptoms, or neurocognition.
    2 context sentences
    Summary · context
    Twenty seven male outpatients with schizophrenia participated in a 6-week (12 session) training on social cognitive skills.
    Summary · context
    Subjects were randomly assigned (double blind) to receive either intranasal OTor placebo 30 min before each session.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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