Effects of cerebrolysin on rat Schwann cells in vitro.

Lucas B, Pinkernelle J, Fansa H, Keilhoff G

Acta histochemica11 Mar 2014Cited by 7 (Europe PMC)

PMID24636538DOI10.1016/j.acthis.2014.01.013PepBankPUB-24636538

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In sciatic nerves in vitro, cerebrolysin accelerated Wallerian degeneration.
In plain wordsIn lab tests, cerebrolysin accelerated Wallerian degeneration in sciatic nerves.
Peptide
Cerebrolysin
Outcome
IncreaseWallerian degeneration
Study
ratn: not reported in source
Sciatic nerves in vitro
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Moreover, CL accelerated WD in vitro.
2 context sentences(design, population, supporting numbers)
Summary · context
Wallerian degeneration (WD) was evaluated by measuring acetylcholine-esterase staining within sciatic nerves in vitro.
Summary · context
Primary SC/fibrocyte co-cultures were prepared from dorsal root ganglia of 5-7-day-old rats.
Report a problemFND-2463653805
02LabIn vitro (cells)Activity measurement
In rat Schwann cell cultures, cerebrolysin did not affect MTT turnover at the tested doses.
In plain wordsIn cells from rats, cerebrolysin did not change MTT turnover.
Peptide
Cerebrolysin
Outcome
No significant changeMTT turnover
Study
ratn: not reported in source
Primary Schwann cell/fibrocyte co-cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
It was found that CL caused no effect on MTT turnover in the tested doses.
1 context sentence(design, population, supporting numbers)
Summary · context
Primary SC/fibrocyte co-cultures were prepared from dorsal root ganglia of 5-7-day-old rats.
Report a problemFND-2463653801
03LabIn vitro (cells)Activity measurement
In rat Schwann cell cultures, cerebrolysin inhibited proliferation in a dose-dependent manner.
In plain wordsIn cells from rats, cerebrolysin reduced Schwann cell proliferation as dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseSchwann cell proliferation
Study
ratn: not reported in source
Primary Schwann cell/fibrocyte co-cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
CL inhibited SC proliferation in a dose-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
Primary SC/fibrocyte co-cultures were prepared from dorsal root ganglia of 5-7-day-old rats.
Report a problemFND-2463653802
04LabIn vitro (cells)Activity measurement
In rat Schwann cell cultures, cerebrolysin enhanced cluster reorganization.
In plain wordsIn cells from rats, cerebrolysin increased Schwann cell cluster reorganization.
Peptide
Cerebrolysin
Outcome
IncreaseSchwann cell cluster reorganization
Study
ratn: not reported in source
Primary Schwann cell/fibrocyte co-cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
CL enhanced the reorganization of SC clusters and was able to counteract SGD-induced cluster defects.
1 context sentence(design, population, supporting numbers)
Summary · context
Primary SC/fibrocyte co-cultures were prepared from dorsal root ganglia of 5-7-day-old rats.
Report a problemFND-2463653803
05LabIn vitro (cells)Activity measurement
In rat Schwann cell cultures, cerebrolysin counteracted serum glucose deprivation-induced cluster defects.
In plain wordsIn cells from rats, cerebrolysin reduced cluster defects caused by glucose deprivation.
Peptide
Cerebrolysin
Outcome
DecreaseGlucose deprivation-induced cluster defects
Study
ratn: not reported in source
Primary Schwann cell/fibrocyte co-cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
CL enhanced the reorganization of SC clusters and was able to counteract SGD-induced cluster defects.
1 context sentence(design, population, supporting numbers)
Summary · context
Primary SC/fibrocyte co-cultures were prepared from dorsal root ganglia of 5-7-day-old rats.
Report a problemFND-2463653804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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