Skip to content

Study · Not a test of the peptide alone · 2014

2 results

AVP neurons in the paraventricular nucleus of the hypothalamus regulate feeding.

Pei H, Sutton AK, Burnett KH, Fuller PM, Olson DP

Molecular metabolism8 Jan 2014Cited by 120 (Europe PMC)

PMID24634830 (opens in a new tab)PMCIDPMC3953699 (opens in a new tab)DOI10.1016/j.molmet.2013.12.006 (opens in a new tab)PepBankPUB-24634830
Read at sourcePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 01AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In mice, DREADD inhibition of PVH-AVP neurons partially reversed melanocortin-induced anorexia.

    In plain wordsIn mice, switching off PVH-AVP neurons partly reversed the loss of appetite that a melanocortin drug caused.

    Peptide
    Melanotan II
    Outcome
    IncreaseMelanocortin-induced anorexia after PVH-AVP neuron inhibition
    Study

    mousen: not reported in source

    AVP-specific Cre-driver mice
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    whereas their inhibition partially reverses melanocortin-induced anorexia.
    1 context sentence
    Summary · context
    To test this, we used an AVP-specific Cre-driver mouse in combination with viral vectors to acutely manipulate PVH-AVP neuron function.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 02AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In mice with virally induced PVH-AVP neuron ablation, MTII did not fully suppress feeding.

    In plain wordsIn mice lacking PVH-AVP neurons, MTII did not fully reduce eating.

    Peptide
    Melanotan II
    Outcome
    IncreaseMTII suppression of feeding after PVH-AVP neuron ablation
    Study

    mousen: not reported in source

    AVP-specific Cre-driver mice
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    We further show that MTII fails to fully suppress feeding in mice with virally-induced PVH-AVP neuron ablation.
    1 context sentence
    Summary · context
    To test this, we used an AVP-specific Cre-driver mouse in combination with viral vectors to acutely manipulate PVH-AVP neuron function.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.