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Study · Measured the body's own peptide · 2014

6 results

Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders.

Rubin LH, Carter CS, Bishop JR, Pournajafi-Nazarloo H, Drogos LL, Hill SK, Ruocco AC, Keedy SK, Reilly JL, Keshavan MS, Pearlson GD, Tamminga CA, Gershon ES, Sweeney JA

Schizophrenia bulletin11 Mar 2014Cited by 72 (Europe PMC)

PMID24619535 (opens in a new tab)PMCIDPMC4193712 (opens in a new tab)DOI10.1093/schbul/sbu027 (opens in a new tab)PepBankPUB-24619535
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In people with schizophrenia, schizoaffective disorder or psychotic bipolar disorder, their relatives and healthy controls, serum levels of the body's own oxytocin did not differ between groups.

    In plain wordsNatural oxytocin levels in the blood were similar in people with psychotic disorders, their relatives and healthy controls.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum oxytocin level between groups
    Study

    n = 427

    Comparator
    Healthy controls
    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    OT levels did not differ between groups.
    1 context sentence
    Summary · context
    We compared abnormalities of OT and AVP serum concentrations in probands with schizophrenia (n = 57), schizoaffective disorder (n = 34), and psychotic bipolar disorder (n = 75); their first-degree relatives without a history of psychosis (n = 61, 43, 91, respectively); and healthy controls (n = 66)…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In healthy controls, higher serum levels of the body's own oxytocin were associated with better emotion recognition.

    In plain wordsIn healthy people, higher natural oxytocin levels were linked to better recognition of emotions.

    Peptide
    Oxytocin
    Outcome
    IncreaseAssociation of oxytocin level with emotion recognition in healthy controls
    Study

    n = 66

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    beta
    0.4
    emotion recognition, healthy controls

    Source sentences

    Summary
    Higher levels of OT were associated with better emotion recognition (β = 0.40, P < .001) and general neuropsychological function (β = 0.26, P = .04) in healthy controls as expected but not in any proband or relative group.
    1 context sentence
    Summary · context
    We compared abnormalities of OT and AVP serum concentrations in probands with schizophrenia (n = 57), schizoaffective disorder (n = 34), and psychotic bipolar disorder (n = 75); their first-degree relatives without a history of psychosis (n = 61, 43, 91, respectively); and healthy controls (n = 66)…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In healthy controls, higher serum levels of the body's own oxytocin were associated with better general neuropsychological function.

    In plain wordsIn healthy people, higher natural oxytocin levels were linked to better general thinking skills.

    Peptide
    Oxytocin
    Outcome
    IncreaseAssociation of oxytocin level with general neuropsychological function in healthy controls
    Study

    n = 66

    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    beta
    0.26
    neuropsychological function, healthy controls

    Source sentences

    Summary
    Higher levels of OT were associated with better emotion recognition (β = 0.40, P < .001) and general neuropsychological function (β = 0.26, P = .04) in healthy controls as expected but not in any proband or relative group.
    1 context sentence
    Summary · context
    We compared abnormalities of OT and AVP serum concentrations in probands with schizophrenia (n = 57), schizoaffective disorder (n = 34), and psychotic bipolar disorder (n = 75); their first-degree relatives without a history of psychosis (n = 61, 43, 91, respectively); and healthy controls (n = 66)…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In people with schizophrenia, higher serum levels of the body's own oxytocin were related to greater positive symptom severity.

    In plain wordsIn people with schizophrenia, higher natural oxytocin levels were linked to more severe positive symptoms.

    Peptide
    Oxytocin
    Outcome
    IncreaseAssociation of oxytocin level with positive symptom severity in schizophrenia
    Study

    n = 57

    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    In schizophrenia, higher OT levels were related to greater positive symptom severity.
    1 context sentence
    Summary · context
    We compared abnormalities of OT and AVP serum concentrations in probands with schizophrenia (n = 57), schizoaffective disorder (n = 34), and psychotic bipolar disorder (n = 75); their first-degree relatives without a history of psychosis (n = 61, 43, 91, respectively); and healthy controls (n = 66)…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In families with psychotic disorders, serum levels of the body's own oxytocin showed robust familiality.

    In plain wordsNatural oxytocin levels in the blood ran strongly in families.

    Peptide
    Oxytocin
    Outcome
    Not applicableFamiliality of serum oxytocin level
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones

    Measurements

    Familiality estimate (h2)
    0.79 h2
    oxytocin

    Source sentences

    Summary
    Familiality estimates were robust for OT (h(2) = 0.79, P = 3.97e-15)
    1 context sentence
    Summary · context
    We compared abnormalities of OT and AVP serum concentrations in probands with schizophrenia (n = 57), schizoaffective disorder (n = 34), and psychotic bipolar disorder (n = 75); their first-degree relatives without a history of psychosis (n = 61, 43, 91, respectively); and healthy controls (n = 66)…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    In probands with psychotic disorders and in their relatives, serum levels of the body's own oxytocin were not associated with emotion recognition or neuropsychological function.

    In plain wordsIn people with psychotic disorders and their relatives, natural oxytocin levels were not linked to emotion recognition or thinking skills.

    Peptide
    Oxytocin
    Outcome
    No significant changeAssociation of oxytocin level with behavioral function in proband and relative groups
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Higher levels of OT were associated with better emotion recognition (β = 0.40, P < .001) and general neuropsychological function (β = 0.26, P = .04) in healthy controls as expected but not in any proband or relative group.
    1 context sentence
    Summary · context
    We compared abnormalities of OT and AVP serum concentrations in probands with schizophrenia (n = 57), schizoaffective disorder (n = 34), and psychotic bipolar disorder (n = 75); their first-degree relatives without a history of psychosis (n = 61, 43, 91, respectively); and healthy controls (n = 66)…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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