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Study · Animal study (in vivo) · mouse · 2014

5 results

Ghrelin receptor agonist, GHRP-2, produces antinociceptive effects at the supraspinal level via the opioid receptor in mice.

Zeng P, Li S, Zheng YH, Liu FY, Wang JL, Zhang DL, Wei J

Peptides4 Mar 2014Cited by 14 (Europe PMC)

PMID24607724 (opens in a new tab)DOI10.1016/j.peptides.2014.02.013 (opens in a new tab)PepBankPUB-24607724
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intracerebroventricular GHRP‑2 produced a concentration- and time-related antinociceptive effect in the tail immersion test.

    In plain wordsIn mice, GHRP‑2 given into the brain reduced pain responses, and the effect grew with concentration and time.

    Peptide
    GHRP-2
    Outcome
    IncreaseAntinociceptive effect in tail immersion test
    Study

    mousen: not reported in source

    Tail immersion test in mice
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.1, 0.3, 1, 3 and 10 nmol/L · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Intracerebroventricular (i.c.v.) administration of GHRP-2 (0.1, 0.3, 1, 3 and 10 nmol/L) produced a concentration- and time-related antinociceptive effect.
    1 context sentence
    Summary · context
    Therefore the aim of this study was to investigate the effects of GHRP-2 on pain modulation at supraspinal level in mice using the tail immersion test.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, the GHS-R1α antagonist [d-Lys(3)]-GHRP-6 fully antagonized the analgesic effect of GHRP‑2, indicating mediation through GHS-R1α.

    In plain wordsIn mice, a ghrelin receptor blocker fully stopped the pain-relieving effect of GHRP‑2, which points to that receptor.

    Peptide
    GHRP-2
    Outcome
    Not applicableBlock of GHRP-2 analgesia by GHS-R1a antagonist
    Study

    mousen: not reported in source

    Tail immersion test in mice
    Comparator
    GHRP-2 without antagonist
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    This effect could be fully antagonized by GHS-R1α antagonist [d-Lys(3)]-GHRP-6, indicating that the analgesic effect induced by GHRP-2 is mediated through the activation of GHS-R1α.
    1 context sentence
    Summary · context
    Therefore the aim of this study was to investigate the effects of GHRP-2 on pain modulation at supraspinal level in mice using the tail immersion test.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, naloxone, naltrindole and nor-binaltorphimine, but not β-funaltrexamine, markedly blocked the analgesic effect of GHRP‑2, suggesting δ- and κ-opioid receptor involvement.

    In plain wordsIn mice, some opioid receptor blockers, but not all, stopped the pain-relieving effect of GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    Not applicableBlock of GHRP-2 analgesia by opioid receptor antagonists
    Study

    mousen: not reported in source

    Tail immersion test in mice
    Comparator
    GHRP-2 without antagonist
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Interestingly, naloxone, naltrindole and nor-binaltorphimine, but not β-funaltrexamine, could also block the analgesic effect markedly, suggesting that δ- and κ-opioid receptor is involved in the analgesic response evoked by GHRP-2.
    1 context sentence
    Summary · context
    Therefore the aim of this study was to investigate the effects of GHRP-2 on pain modulation at supraspinal level in mice using the tail immersion test.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intracerebroventricular GHRP‑2 potentiated the analgesic effect induced by intracerebroventricular morphine (1 nmol/L).

    In plain wordsIn mice, GHRP‑2 given into the brain strengthened the pain relief from morphine.

    Peptide
    GHRP-2
    Outcome
    IncreasePotentiation of morphine analgesia
    Study

    mousen: not reported in source

    Tail immersion test in mice
    Comparator
    Morphine alone (i.c.v., 1 nmol/L)
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, i.c.v. administration of GHRP-2 potentiated the analgesic effect induced by morphine (i.c.v., 1 nmol/L)
    1 context sentence
    Summary · context
    Therefore the aim of this study was to investigate the effects of GHRP-2 on pain modulation at supraspinal level in mice using the tail immersion test.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, the potentiation of morphine analgesia by GHRP‑2 was not reversed by [d-Lys(3)]-GHRP-6.

    In plain wordsIn mice, the ghrelin receptor blocker did not undo the boost that GHRP‑2 gave to morphine pain relief.

    Peptide
    GHRP-2
    Outcome
    No significant changeReversal of potentiated morphine effect by GHS-R1a antagonist
    Study

    mousen: not reported in source

    Tail immersion test in mice
    Comparator
    GHRP-2 plus morphine without antagonist
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    and this potentiated effect could not be reversed by [d-Lys(3)]-GHRP-6.
    1 context sentence
    Summary · context
    Therefore the aim of this study was to investigate the effects of GHRP-2 on pain modulation at supraspinal level in mice using the tail immersion test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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