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Study · Randomized controlled trial · n = 58 · 2014

13 results

Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples.

Behnia B, Heinrichs M, Bergmann W, Jung S, Germann J, Schedlowski M, Hartmann U, Kruger TH

Hormones and behavior3 Feb 2014Cited by 67 (Europe PMC)

PMID24503174 (opens in a new tab)DOI10.1016/j.yhbeh.2014.01.009 (opens in a new tab)PepBankPUB-24503174
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. 13 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy heterosexual couples, intranasal oxytocin did not alter sexual drive.

    In plain wordsIn healthy couples, oxytocin did not change sexual drive.

    Peptide
    Oxytocin
    Outcome
    No significant changeSexual drive
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal OXT administration did not alter "classical" parameters of sexual function, such as sexual drive, arousal or penile erection and lubrication.
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy heterosexual couples, intranasal oxytocin did not alter sexual arousal.

    In plain wordsIn healthy couples, oxytocin did not change sexual arousal.

    Peptide
    Oxytocin
    Outcome
    No significant changeSexual arousal
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal OXT administration did not alter "classical" parameters of sexual function, such as sexual drive, arousal or penile erection and lubrication.
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy heterosexual couples, intranasal oxytocin did not alter penile erection.

    In plain wordsIn healthy couples, oxytocin did not change erection.

    Peptide
    Oxytocin
    Outcome
    No significant changePenile erection
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal OXT administration did not alter "classical" parameters of sexual function, such as sexual drive, arousal or penile erection and lubrication.
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy heterosexual couples, intranasal oxytocin did not alter lubrication.

    In plain wordsIn healthy couples, oxytocin did not change lubrication.

    Peptide
    Oxytocin
    Outcome
    No significant changeLubrication
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal OXT administration did not alter "classical" parameters of sexual function, such as sexual drive, arousal or penile erection and lubrication.
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In healthy heterosexual couples, intranasal oxytocin increased the intensity of orgasm in a hierarchical linear model analysis.

    In plain wordsIn healthy couples, oxytocin increased how intense orgasm felt.

    Peptide
    Oxytocin
    Outcome
    IncreaseIntensity of orgasm
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    According to HLM analysis, OXT increased the intensity of orgasm
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In healthy heterosexual couples, intranasal oxytocin increased contentment after sexual intercourse in a hierarchical linear model analysis.

    In plain wordsIn healthy couples, oxytocin increased contentment after sex.

    Peptide
    Oxytocin
    Outcome
    IncreaseContentment after sexual intercourse
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    According to HLM analysis, OXT increased the intensity of orgasm, contentment after sexual intercourse and the effect of study participation.
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In healthy heterosexual couples, intranasal oxytocin increased the rated effect of study participation in a hierarchical linear model analysis.

    In plain wordsIn healthy couples, oxytocin increased the rated effect of taking part in the study.

    Peptide
    Oxytocin
    Outcome
    IncreaseEffect of study participation
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    According to HLM analysis, OXT increased the intensity of orgasm, contentment after sexual intercourse and the effect of study participation.
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  8. 08HumanRandomized controlled trialMechanism

    In healthy heterosexual couples, cortisol was not affected by intranasal oxytocin.

    In plain wordsIn healthy couples, oxytocin did not change the stress hormone cortisol.

    Peptide
    Oxytocin
    Outcome
    No significant changeCortisol
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Stress hormones · Whole body
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Biomarkers indicated moderate psychophysiological activation but were not affected by OXT, gender or method of contraception.
    2 context sentences
    Summary · context
    Data were assessed by psychometric instruments (Acute Sexual Experiences Scale, Arizona Sexual Experience Scale) as well as biomarkers, such as cortisol, α-amylase and heart rate.
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  9. 09HumanRandomized controlled trialMechanism

    In healthy heterosexual couples, alpha-amylase was not affected by intranasal oxytocin.

    In plain wordsIn healthy couples, oxytocin did not change alpha-amylase, a marker of stress activation.

    Peptide
    Oxytocin
    Outcome
    No significant changeAlpha-amylase
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Stress hormones · Whole body
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Biomarkers indicated moderate psychophysiological activation but were not affected by OXT, gender or method of contraception.
    2 context sentences
    Summary · context
    Data were assessed by psychometric instruments (Acute Sexual Experiences Scale, Arizona Sexual Experience Scale) as well as biomarkers, such as cortisol, α-amylase and heart rate.
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  10. 10HumanRandomized controlled trialMechanism

    In healthy heterosexual couples, heart rate was not affected by intranasal oxytocin.

    In plain wordsIn healthy couples, oxytocin did not change heart rate.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeart rate
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Biomarkers indicated moderate psychophysiological activation but were not affected by OXT, gender or method of contraception.
    2 context sentences
    Summary · context
    Data were assessed by psychometric instruments (Acute Sexual Experiences Scale, Arizona Sexual Experience Scale) as well as biomarkers, such as cortisol, α-amylase and heart rate.
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  11. 11HumanRandomized controlled trialEfficacy outcome

    In men, intranasal oxytocin was followed by higher levels of sexual satiety after sexual intercourse.

    In plain wordsIn men, oxytocin was linked to feeling more sexually satisfied after sex.

    Peptide
    Oxytocin
    Outcome
    IncreaseSexual satiety after intercourse in men
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Men additionally indicated higher levels of sexual satiety after sexual intercourse with OXT administration.
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  12. 12HumanRandomized controlled trialEfficacy outcome

    In women, intranasal oxytocin was followed by feeling more relaxed.

    In plain wordsIn women, oxytocin was linked to feeling more relaxed.

    Peptide
    Oxytocin
    Outcome
    IncreaseFeeling relaxed in women
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Women felt more relaxed and subgroups indicated better abilities to share sexual desires or to empathize with their partners.
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.
  13. 13HumanRandomized controlled trialEfficacy outcome

    In subgroups of women, intranasal oxytocin was linked to better abilities to share sexual desires or to empathize with partners.

    In plain wordsIn some women, oxytocin was linked to better ability to share sexual desires or to understand their partner.

    Peptide
    Oxytocin
    Outcome
    IncreaseAbility to share sexual desires or empathize with partner in subgroups
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Women felt more relaxed and subgroups indicated better abilities to share sexual desires or to empathize with their partners.
    1 context sentence
    Summary · context
    Employing a naturalistic setting involving 29 healthy heterosexual couples (n=58 participants), we analyzed the acute effects of intranasally administered OXT (24IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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