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Study · Animal study (in vivo) · rat · 2014

5 results

Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death.

Scuderi S, D'Amico AG, Castorina A, Federico C, Marrazzo G, Drago F, Bucolo C, D'Agata V

Journal of molecular neuroscience : MN2 Feb 2014Cited by 30 (Europe PMC)

PMID24488575 (opens in a new tab)DOI10.1007/s12031-014-0244-4 (opens in a new tab)PepBankPUB-24488575
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-diabetic rats, NAP reduced retinal apoptotic events.

    In plain wordsIn diabetic rats, NAP reduced retinal cell death compared with vehicle.

    Peptide
    Davunetide
    Outcome
    DecreaseRetinal apoptotic events
    Study

    ratn: not reported in source

    STZ-induced diabetic retina
    Comparator
    vehicle
    Outcome group
    Neuroprotection · Eye
    Studied dose
    100 μg/mL · intraocularAs given in this study (rat).

    Source sentences

    Summary
    Results demonstrated that NAP treatment reduced apoptotic event in diabetic retina, and it restored cleaved caspase-3 expression levels in the retina of STZ-injected rats as well as the decreased Bcl2.
    2 context sentences
    Summary · context
    A single intraocular injection of NAP (100 μg/mL) or vehicle was administered 1 week after STZ injection.
    Summary · context
    Three weeks after diabetes induction, we assessed the retinal expression and distribution of apoptosis markers, cleaved caspase-3, and Bcl2, by Western blot and immunofluorescent analysis.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In STZ-diabetic rats, NAP restored retinal cleaved caspase-3 expression levels.

    In plain wordsIn diabetic rats, NAP restored retinal cleaved caspase-3 levels compared with vehicle.

    Peptide
    Davunetide
    Outcome
    Direction not reportedRetinal cleaved caspase-3 expression
    Study

    ratn: not reported in source

    STZ-induced diabetic retina
    Comparator
    vehicle
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    100 μg/mL · intraocularAs given in this study (rat).

    Source sentences

    Summary
    Results demonstrated that NAP treatment reduced apoptotic event in diabetic retina, and it restored cleaved caspase-3 expression levels in the retina of STZ-injected rats as well as the decreased Bcl2.
    2 context sentences
    Summary · context
    A single intraocular injection of NAP (100 μg/mL) or vehicle was administered 1 week after STZ injection.
    Summary · context
    Three weeks after diabetes induction, we assessed the retinal expression and distribution of apoptosis markers, cleaved caspase-3, and Bcl2, by Western blot and immunofluorescent analysis.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In STZ-diabetic rats, NAP restored decreased retinal Bcl2 expression.

    In plain wordsIn diabetic rats, NAP restored reduced retinal Bcl2 levels compared with vehicle.

    Peptide
    Davunetide
    Outcome
    IncreaseRetinal Bcl2 expression
    Study

    ratn: not reported in source

    STZ-induced diabetic retina
    Comparator
    vehicle
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    100 μg/mL · intraocularAs given in this study (rat).

    Source sentences

    Summary
    Results demonstrated that NAP treatment reduced apoptotic event in diabetic retina, and it restored cleaved caspase-3 expression levels in the retina of STZ-injected rats as well as the decreased Bcl2.
    2 context sentences
    Summary · context
    A single intraocular injection of NAP (100 μg/mL) or vehicle was administered 1 week after STZ injection.
    Summary · context
    Three weeks after diabetes induction, we assessed the retinal expression and distribution of apoptosis markers, cleaved caspase-3, and Bcl2, by Western blot and immunofluorescent analysis.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-diabetic rats, NAP improved cellular survival through MAPK/ERK pathway activation.

    In plain wordsIn diabetic rats, NAP improved retinal cell survival compared with vehicle.

    Peptide
    Davunetide
    Outcome
    IncreaseRetinal cellular survival
    Study

    ratn: not reported in source

    STZ-induced diabetic retina
    Comparator
    vehicle
    Outcome group
    Neuroprotection · Eye
    Studied dose
    100 μg/mL · intraocularAs given in this study (rat).

    Source sentences

    Summary
    NAP treatment improved cellular survival through the activation of the MAPK/ERK pathway.
    2 context sentences
    Summary · context
    A single intraocular injection of NAP (100 μg/mL) or vehicle was administered 1 week after STZ injection.
    Summary · context
    Three weeks after diabetes induction, we assessed the retinal expression and distribution of apoptosis markers, cleaved caspase-3, and Bcl2, by Western blot and immunofluorescent analysis.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In STZ-diabetic rats, NAP activated the MAPK/ERK pathway.

    In plain wordsIn diabetic rats, NAP activated the MAPK/ERK pathway compared with vehicle.

    Peptide
    Davunetide
    Outcome
    IncreaseMAPK/ERK pathway activation
    Study

    ratn: not reported in source

    STZ-induced diabetic retina
    Comparator
    vehicle
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    100 μg/mL · intraocularAs given in this study (rat).

    Source sentences

    Summary
    NAP treatment improved cellular survival through the activation of the MAPK/ERK pathway.
    2 context sentences
    Summary · context
    A single intraocular injection of NAP (100 μg/mL) or vehicle was administered 1 week after STZ injection.
    Summary · context
    Three weeks after diabetes induction, we assessed the retinal expression and distribution of apoptosis markers, cleaved caspase-3, and Bcl2, by Western blot and immunofluorescent analysis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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