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Study · Measured the body's own peptide · 2014

2 results

Changes in biochemical markers of pain perception and stress response after spinal manipulation.

Plaza-Manzano G, Molina-Ortega F, Lomas-Vega R, Martínez-Amat A, Achalandabaso A, Hita-Contreras F

The Journal of orthopaedic and sports physical therapy22 Jan 2014Cited by 38 (Europe PMC)

PMID24450367 (opens in a new tab)DOI10.2519/jospt.2014.4996 (opens in a new tab)PepBankPUB-24450367
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In asymptomatic adults, plasma levels of the body's own oxytocin were higher immediately after cervical and thoracic spinal manipulation (P<.001).

    In plain wordsIn healthy adults, the body's own oxytocin levels in blood rose right after neck and upper back manipulation.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin immediately after cervical or thoracic manipulation
    Study

    n = 30

    Comparator
    Non-manipulation control group
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Immediately after the intervention, significantly higher values of neurotensin (P<.05) and oxytocin (P<.001) levels were observed with both cervical and thoracic manipulation
    1 context sentence
    Summary · context
    Thirty asymptomatic subjects were randomly divided into 3 groups: cervical manipulation (n = 10), thoracic manipulation (n = 10), and nonmanipulation (control) (n = 10).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In asymptomatic adults, plasma levels of the body's own oxytocin showed no significant between-group differences two hours after spinal manipulation.

    In plain wordsIn healthy adults, the body's own oxytocin levels in blood no longer differed between groups two hours after manipulation.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin two hours after manipulation
    Study

    n = 30

    Comparator
    Non-manipulation control group
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Two hours after the intervention, no significant differences were observed in between-group analysis.
    1 context sentence
    Summary · context
    Thirty asymptomatic subjects were randomly divided into 3 groups: cervical manipulation (n = 10), thoracic manipulation (n = 10), and nonmanipulation (control) (n = 10).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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