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Study · Animal study (in vivo) · rat · 2013

3 results

[Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank].

Kolomin TA, Agapova TIu, Agniullin IaV, Shram SI, Shadrina MI, Slominskiĭ PA, Limborskaia SA, Miasoedov IF

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 May 2013Cited by 2 (Europe PMC)

PMID24450168 (opens in a new tab)DOI10.7868/s0044467713030052 (opens in a new tab)PepBankPUB-24450168
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, a single intranasal selank dose changed the mRNA levels of 36 hippocampal genes by more than 2-fold.

    In plain wordsIn rats, one nasal dose of selank changed the activity of 36 genes in the hippocampus by more than 2-fold.

    Peptide
    Selank
    Outcome
    Direction not reportedHippocampal gene expression after single dose
    Study

    ratn: not reported in source

    Hippocampus (cDNA microarray)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    200 microg/kg · intranasalAs given in this study (rat).

    Measurements

    Genes changed >2-fold
    36 genes
    single intranasal dose

    Source sentences

    Summary
    mRNA levels of 36 genes changed more than 2-fold after a single intranasal Selank administration
    1 context sentence
    Summary · context
    The effect of single and course administration of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) in the dose 200 microg/kg on the rat hippocampus transcriptional profile were studied using cDNA microarray technology.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, course administration of selank changed the mRNA levels of 20 hippocampal genes by more than 2-fold.

    In plain wordsIn rats, a course of selank doses changed the activity of 20 genes in the hippocampus by more than 2-fold.

    Peptide
    Selank
    Outcome
    Direction not reportedHippocampal gene expression after course dosing
    Study

    ratn: not reported in source

    Hippocampus (cDNA microarray)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    200 microg/kgAs given in this study (rat).

    Measurements

    Genes changed >2-fold
    20 genes
    course administration

    Source sentences

    Summary
    mRNA levels of 36 genes changed more than 2-fold after a single intranasal Selank administration, and 20 genes--after course administration
    1 context sentence
    Summary · context
    The effect of single and course administration of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) in the dose 200 microg/kg on the rat hippocampus transcriptional profile were studied using cDNA microarray technology.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, most hippocampal genes changed by selank encode proteins associated with the plasma membrane, including transmembrane proteins.

    In plain wordsIn rats, most hippocampal genes changed by selank code for proteins linked to the cell membrane.

    Peptide
    Selank
    Outcome
    Not applicableFunction of genes with changed expression
    Study

    ratn: not reported in source

    Hippocampus (cDNA microarray)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    200 microg/kgAs given in this study (rat).

    Source sentences

    Summary
    It should be noted that most of them encode proteins associated with the plasma membrane (including transmembrane proteins).
    1 context sentence
    Summary · context
    The effect of single and course administration of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) in the dose 200 microg/kg on the rat hippocampus transcriptional profile were studied using cDNA microarray technology.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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