[Effects of the δ-sleep inducing peptide on neuronal activity in the dorsal hippocampus of rats with different behavior in the open field after stimulation of the positive and negative emotionalistic structures of the brain].

Grigorchuk OS

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 May 2013

PMID24450167DOI10.7868/s0044467713030040PepBankPUB-24450167

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In active and passive Wistar rats, microiontophoretic DSIP before lateral hypothalamus stimulation decreased dorsal hippocampus neuronal responses.
In plain wordsIn rats, DSIP applied to hippocampal neurons reduced their responses to stimulation of a brain area linked to positive emotion.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseHippocampal neuron response to LH stimulation
Study
ratn: not reported in source
dorsal hippocampus neurons, electric stimulation of lateral and ventromedial hypothalamus
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · microiontophoretic applicationAs given in this study (rat).
Source sentences
Summary
DSIP microiontophoretic application before LH stimulation decreases neuronal responses in both active and passive animals.
1 context sentence(design, population, supporting numbers)
Summary · context
In 20 male Wistar rats 107 neurons of dorsal hippocampus (57 neurons in active in open field--prognostically resistant to emotional stress and 50 inpassive--prognostically predisposed rats) were registered after positive (lateral hypothalamus--LH) and negative (ventromedial hypothalamus--VMH) emotio…
Report a problemFND-2445016701
02AnimalAnimal study (in vivo)Mechanism
In behaviourally active rats, DSIP increased dorsal hippocampus neuron sensitivity to ventromedial hypothalamus stimulation.
In plain wordsIn active rats, DSIP made hippocampal neurons more sensitive to stimulation of a brain area linked to negative emotion.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHippocampal neuron sensitivity to VMH stimulation, active rats
Study
ratn: not reported in source
dorsal hippocampus neurons, electric stimulation of lateral and ventromedial hypothalamus
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · microiontophoretic applicationAs given in this study (rat).
Source sentences
Summary
DSIP increases dorsal hippocampus neurons sensitivity to VMH stimulation in active rats and decreases in passive ones.
1 context sentence(design, population, supporting numbers)
Summary · context
In 20 male Wistar rats 107 neurons of dorsal hippocampus (57 neurons in active in open field--prognostically resistant to emotional stress and 50 inpassive--prognostically predisposed rats) were registered after positive (lateral hypothalamus--LH) and negative (ventromedial hypothalamus--VMH) emotio…
Report a problemFND-2445016702
03AnimalAnimal study (in vivo)Mechanism
In behaviourally passive rats, DSIP decreased dorsal hippocampus neuron sensitivity to ventromedial hypothalamus stimulation.
In plain wordsIn passive rats, DSIP made hippocampal neurons less sensitive to stimulation of a brain area linked to negative emotion.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseHippocampal neuron sensitivity to VMH stimulation, passive rats
Study
ratn: not reported in source
dorsal hippocampus neurons, electric stimulation of lateral and ventromedial hypothalamus
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · microiontophoretic applicationAs given in this study (rat).
Source sentences
Summary
DSIP increases dorsal hippocampus neurons sensitivity to VMH stimulation in active rats and decreases in passive ones.
1 context sentence(design, population, supporting numbers)
Summary · context
In 20 male Wistar rats 107 neurons of dorsal hippocampus (57 neurons in active in open field--prognostically resistant to emotional stress and 50 inpassive--prognostically predisposed rats) were registered after positive (lateral hypothalamus--LH) and negative (ventromedial hypothalamus--VMH) emotio…
Report a problemFND-2445016703

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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