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Study · Randomized controlled trial · n = 65 · 2014

3 results

Effects of MDMA and Intranasal oxytocin on social and emotional processing.

Kirkpatrick MG, Lee R, Wardle MC, Jacob S, de Wit H

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology22 Jan 2014Cited by 117 (Europe PMC)

PMID24448644 (opens in a new tab)PMCIDPMC4023138 (opens in a new tab)DOI10.1038/npp.2014.12 (opens in a new tab)PepBankPUB-24448644
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In MDMA users, intranasal oxytocin produced small but significant increases in feelings of sociability compared with placebo.

    In plain wordsIn MDMA users, oxytocin gave a small increase in feelings of sociability compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseFeelings of sociability
    Study

    n = 65

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    20 or 40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin produced small but significant increases in feelings of sociability
    1 context sentence
    Summary · context
    MDMA users (N = 65) participated in a 4-session, within-between-subjects study in which they received oral MDMA (0.75, 1.5 mg/kg), intranasal oxytocin (20 or 40 IU), or placebo under double-blind conditions.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In MDMA users, intranasal oxytocin enhanced recognition of sad facial expressions compared with placebo.

    In plain wordsIn MDMA users, oxytocin improved recognition of sad faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseRecognition of sad facial expressions
    Study

    n = 65

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    20 or 40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    and enhanced recognition of sad facial expressions
    1 context sentence
    Summary · context
    MDMA users (N = 65) participated in a 4-session, within-between-subjects study in which they received oral MDMA (0.75, 1.5 mg/kg), intranasal oxytocin (20 or 40 IU), or placebo under double-blind conditions.
  3. 03HumanRandomized controlled trialMechanism

    In MDMA users, responses to oxytocin were related to responses to MDMA on two subjective measures of sociability.

    In plain wordsIn MDMA users, people who responded to oxytocin also tended to respond to MDMA on two measures of sociability.

    Peptide
    Oxytocin
    Outcome
    Not applicableRelation between responses to oxytocin and responses to MDMA on sociability measures
    Study

    n = 65

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    20 or 40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Additionally, responses to oxytocin were related to responses to MDMA with subjects on two subjective measures of sociability.
    1 context sentence
    Summary · context
    MDMA users (N = 65) participated in a 4-session, within-between-subjects study in which they received oral MDMA (0.75, 1.5 mg/kg), intranasal oxytocin (20 or 40 IU), or placebo under double-blind conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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