AMPK agonist AICAR improves cognition and motor coordination in young and aged mice.

Kobilo T, Guerrieri D, Zhang Y, Collica SC, Becker KG, van Praag H

Learning & memory (Cold Spring Harbor, N.Y.)17 Jan 2014Cited by 110 (Europe PMC)

PMID24443745PMCIDPMC3895225DOI10.1101/lm.033332.113PepBankPUB-24443745

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Summary

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Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In young mice, AICAR improved water maze performance after the shorter administration period.
In plain wordsIn young mice, AICAR improved water maze performance.
Peptide
AICAR (acadesine)
Outcome
IncreaseWater maze performance in young mice
Study
mousen: not reported in source
female C57Bl/6 mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
500 mg/kg · injection · 3 daysAs given in this study (mouse).
Source sentences
Summary
Improved water maze performance and motor function were observed, albeit at longer duration of administration, in aged (14-d AICAR) than in young (3-d AICAR) mice.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5- to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4- to 6-wk-old) transgenic mice with muscle-specific mutated AMPK α2-subunit (AMPK-DN).
Summary · context
Mice were injected with AICAR (500 mg/kg) for 3-14 d.
Report a problemFND-2444374501
02AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, AICAR improved water maze performance with a longer administration period than in young mice.
In plain wordsIn aged mice, AICAR improved water maze performance after longer treatment than young mice required.
Peptide
AICAR (acadesine)
Outcome
IncreaseWater maze performance in aged mice
Study
mousen: not reported in source
female C57Bl/6 mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
500 mg/kg · injection · 14 daysAs given in this study (mouse).
Source sentences
Summary
Improved water maze performance and motor function were observed, albeit at longer duration of administration, in aged (14-d AICAR) than in young (3-d AICAR) mice.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5- to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4- to 6-wk-old) transgenic mice with muscle-specific mutated AMPK α2-subunit (AMPK-DN).
Summary · context
Mice were injected with AICAR (500 mg/kg) for 3-14 d.
Report a problemFND-2444374502
03AnimalAnimal study (in vivo)Efficacy outcome
In young mice, AICAR improved motor function after the shorter administration period.
In plain wordsIn young mice, AICAR improved movement function.
Peptide
AICAR (acadesine)
Outcome
IncreaseMotor function in young mice
Study
mousen: not reported in source
female C57Bl/6 mice
Outcome group
Exercise and physical function · Musculoskeletal
Studied dose
500 mg/kg · injection · 3 daysAs given in this study (mouse).
Source sentences
Summary
Improved water maze performance and motor function were observed, albeit at longer duration of administration, in aged (14-d AICAR) than in young (3-d AICAR) mice.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5- to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4- to 6-wk-old) transgenic mice with muscle-specific mutated AMPK α2-subunit (AMPK-DN).
Summary · context
Mice were injected with AICAR (500 mg/kg) for 3-14 d.
Report a problemFND-2444374503
04AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, AICAR improved motor function with a longer administration period than in young mice.
In plain wordsIn aged mice, AICAR improved movement function after longer treatment than young mice required.
Peptide
AICAR (acadesine)
Outcome
IncreaseMotor function in aged mice
Study
mousen: not reported in source
female C57Bl/6 mice
Outcome group
Exercise and physical function · Musculoskeletal
Studied dose
500 mg/kg · injection · 14 daysAs given in this study (mouse).
Source sentences
Summary
Improved water maze performance and motor function were observed, albeit at longer duration of administration, in aged (14-d AICAR) than in young (3-d AICAR) mice.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5- to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4- to 6-wk-old) transgenic mice with muscle-specific mutated AMPK α2-subunit (AMPK-DN).
Summary · context
Mice were injected with AICAR (500 mg/kg) for 3-14 d.
Report a problemFND-2444374504
05AnimalAnimal study (in vivo)Efficacy outcome
In AMPK-DN mice, AICAR did not enhance behavior.
In plain wordsIn mice with mutated muscle AMPK, AICAR did not improve behavior.
Peptide
AICAR (acadesine)
Outcome
No significant changeBehavior in AMPK-DN mice
Study
mousen: not reported in source
AMPK-DN mice
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
500 mg/kg · injectionAs given in this study (mouse).
Source sentences
Summary
In the AMPK-DN mice, the compound did not enhance behavior, providing support for a muscle-mediated mechanism.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5- to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4- to 6-wk-old) transgenic mice with muscle-specific mutated AMPK α2-subunit (AMPK-DN).
Summary · context
Mice were injected with AICAR (500 mg/kg) for 3-14 d.
Report a problemFND-2444374505
06AnimalAnimal study (in vivo)Mechanism
In aged mice given AICAR, muscle gene expression changed and correlated with behavioral effects in a dose-dependent manner.
In plain wordsIn aged mice given AICAR, muscle gene changes correlated with behavioral effects in a dose-dependent manner.
Peptide
AICAR (acadesine)
Outcome
Direction not reportedMuscle gene expression
Study
mousen: not reported in source
aged mice
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
500 mg/kg · injectionAs given in this study (mouse).
Source sentences
Summary
In addition, microarray analysis of muscle and hippocampal tissue derived from aged mice treated with AICAR revealed changes in gene expression in both tissues, which correlated with behavioral effects in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5- to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4- to 6-wk-old) transgenic mice with muscle-specific mutated AMPK α2-subunit (AMPK-DN).
Summary · context
Mice were injected with AICAR (500 mg/kg) for 3-14 d.
Report a problemFND-2444374506
07AnimalAnimal study (in vivo)Mechanism
In aged mice given AICAR, hippocampal gene expression changed and correlated with behavioral effects in a dose-dependent manner.
In plain wordsIn aged mice given AICAR, hippocampal gene changes correlated with behavioral effects in a dose-dependent manner.
Peptide
AICAR (acadesine)
Outcome
Direction not reportedHippocampal gene expression
Study
mousen: not reported in source
aged mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
500 mg/kg · injectionAs given in this study (mouse).
Source sentences
Summary
In addition, microarray analysis of muscle and hippocampal tissue derived from aged mice treated with AICAR revealed changes in gene expression in both tissues, which correlated with behavioral effects in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5- to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4- to 6-wk-old) transgenic mice with muscle-specific mutated AMPK α2-subunit (AMPK-DN).
Summary · context
Mice were injected with AICAR (500 mg/kg) for 3-14 d.
Report a problemFND-2444374507
08AnimalAnimal study (in vivo)Mechanism
In aged mice given AICAR, muscle mitochondrial genes showed pronounced upregulation.
In plain wordsIn aged mice given AICAR, muscle mitochondrial gene expression increased.
Peptide
AICAR (acadesine)
Outcome
IncreaseMuscle mitochondrial genes
Study
mousen: not reported in source
aged mice
Outcome group
Mitochondrial function · Musculoskeletal
Studied dose
500 mg/kg · injectionAs given in this study (mouse).
Source sentences
Summary
Pronounced up-regulation of mitochondrial genes in muscle was observed.
3 context sentences(design, population, supporting numbers)
Summary · context
In addition, microarray analysis of muscle and hippocampal tissue derived from aged mice treated with AICAR revealed changes in gene expression in both tissues, which correlated with behavioral effects in a dose-dependent manner.
Summary · context
In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5- to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4- to 6-wk-old) transgenic mice with muscle-specific mutated AMPK α2-subunit (AMPK-DN).
Summary · context
Mice were injected with AICAR (500 mg/kg) for 3-14 d.
Report a problemFND-2444374508
09AnimalAnimal study (in vivo)Mechanism
In aged mice given AICAR, hippocampal genes related to neuronal development and plasticity were enriched.
In plain wordsIn aged mice given AICAR, hippocampal genes related to nerve development and adaptability were enriched.
Peptide
AICAR (acadesine)
Outcome
Not applicableHippocampal neuronal development and plasticity genes
Study
mousen: not reported in source
aged mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
500 mg/kg · injectionAs given in this study (mouse).
Source sentences
Summary
In the hippocampus, genes relevant to neuronal development and plasticity were enriched.
3 context sentences(design, population, supporting numbers)
Summary · context
In addition, microarray analysis of muscle and hippocampal tissue derived from aged mice treated with AICAR revealed changes in gene expression in both tissues, which correlated with behavioral effects in a dose-dependent manner.
Summary · context
In the present study we investigated effects of AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) on memory and motor function in young (5- to 7-wk-old) and aged (23-mo-old) female C57Bl/6 mice, and in young (4- to 6-wk-old) transgenic mice with muscle-specific mutated AMPK α2-subunit (AMPK-DN).
Summary · context
Mice were injected with AICAR (500 mg/kg) for 3-14 d.
Report a problemFND-2444374509

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

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