[The effect of cerebrolysin on the regeneration of the peripheral nerve depending on the scheme of paraneural administration].

Shchudlo NA, Shchudlo MM, Borisova IV

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2013Cited by 1 (Europe PMC)

PMID24430040PepBankPUB-24430040

Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In animals after nerve transection and suturing, cerebrolysin stimulated regenerative growth of nerve fiber axial cylinders.
In plain wordsIn animals after nerve injury and repair, cerebrolysin stimulated nerve fiber growth.
Peptide
Cerebrolysin
Outcome
IncreaseNerve fiber axial cylinder growth
Study
n: not reported in source
Peripheral nerve transection and microsurgical suturing
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · paraneural infusionAs given in this study.
Source sentences
Summary
There was a stimulating effect of the preparation on the regenerative growth and differentiation of nerve fiber axial cylinders, vascularization of the distal segment of regenerating nerve and the trophic condition of myelin-forming Schwann cells.
1 context sentence(design, population, supporting numbers)
Summary · context
An experimental morphological study in 56 animals has been performed in order to analyze the effect of cerebrolysin on the dynamics and long-term results of peripheral nerve regeneration after the transection and microsurgical suturing depending on the scheme of the preparation of paraneural infusion.
Report a problemFND-2443004001
02AnimalAnimal study (in vivo)Efficacy outcome
In animals after nerve transection and suturing, cerebrolysin stimulated differentiation of nerve fiber axial cylinders.
In plain wordsIn animals after nerve injury and repair, cerebrolysin stimulated nerve fiber differentiation.
Peptide
Cerebrolysin
Outcome
IncreaseNerve fiber axial cylinder differentiation
Study
n: not reported in source
Peripheral nerve transection and microsurgical suturing
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · paraneural infusionAs given in this study.
Source sentences
Summary
There was a stimulating effect of the preparation on the regenerative growth and differentiation of nerve fiber axial cylinders, vascularization of the distal segment of regenerating nerve and the trophic condition of myelin-forming Schwann cells.
1 context sentence(design, population, supporting numbers)
Summary · context
An experimental morphological study in 56 animals has been performed in order to analyze the effect of cerebrolysin on the dynamics and long-term results of peripheral nerve regeneration after the transection and microsurgical suturing depending on the scheme of the preparation of paraneural infusion.
Report a problemFND-2443004002
03AnimalAnimal study (in vivo)Efficacy outcome
In animals after nerve transection and suturing, cerebrolysin stimulated vascularization of the distal regenerating nerve segment.
In plain wordsIn animals after nerve injury and repair, cerebrolysin improved blood vessel formation in the regenerating nerve.
Peptide
Cerebrolysin
Outcome
IncreaseDistal nerve vascularization
Study
n: not reported in source
Peripheral nerve transection and microsurgical suturing
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · paraneural infusionAs given in this study.
Source sentences
Summary
There was a stimulating effect of the preparation on the regenerative growth and differentiation of nerve fiber axial cylinders, vascularization of the distal segment of regenerating nerve and the trophic condition of myelin-forming Schwann cells.
1 context sentence(design, population, supporting numbers)
Summary · context
An experimental morphological study in 56 animals has been performed in order to analyze the effect of cerebrolysin on the dynamics and long-term results of peripheral nerve regeneration after the transection and microsurgical suturing depending on the scheme of the preparation of paraneural infusion.
Report a problemFND-2443004003
04AnimalAnimal study (in vivo)Efficacy outcome
In animals after nerve transection and suturing, cerebrolysin improved the trophic condition of myelin-forming Schwann cells.
In plain wordsIn animals after nerve injury and repair, cerebrolysin improved the condition of myelin-forming Schwann cells.
Peptide
Cerebrolysin
Outcome
IncreaseSchwann cell trophic condition
Study
n: not reported in source
Peripheral nerve transection and microsurgical suturing
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · paraneural infusionAs given in this study.
Source sentences
Summary
There was a stimulating effect of the preparation on the regenerative growth and differentiation of nerve fiber axial cylinders, vascularization of the distal segment of regenerating nerve and the trophic condition of myelin-forming Schwann cells.
1 context sentence(design, population, supporting numbers)
Summary · context
An experimental morphological study in 56 animals has been performed in order to analyze the effect of cerebrolysin on the dynamics and long-term results of peripheral nerve regeneration after the transection and microsurgical suturing depending on the scheme of the preparation of paraneural infusion.
Report a problemFND-2443004004
05AnimalAnimal study (in vivo)Efficacy outcome
In animals after nerve repair, the prolonged cerebrolysin regimen retained its effect for up to 10.5 months after paraneural injections ended.
In plain wordsIn animals after nerve repair, the prolonged cerebrolysin regimen retained its effect for up to 10.5 months after injections ended.
Peptide
Cerebrolysin
Outcome
Not applicablePersistence of regenerative effect
Study
n: not reported in source
Peripheral nerve transection and microsurgical suturing
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · paraneural infusionAs given in this study.
Measurements
Effect persistence
≤ 10.5 months
after injection course
Source sentences
Summary
When the preparation is used according to the prolonged scheme, the effect persists for up to 10.5 months after the end of paraneural injection course.
1 context sentence(design, population, supporting numbers)
Summary · context
An experimental morphological study in 56 animals has been performed in order to analyze the effect of cerebrolysin on the dynamics and long-term results of peripheral nerve regeneration after the transection and microsurgical suturing depending on the scheme of the preparation of paraneural infusion.
Report a problemFND-2443004005

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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