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Study · Animal study (in vivo) · rat · 2013

12 results

Cerebrolysin attenuates cerebral and hepatic injury due to lipopolysaccharide in rats.

Abdel-Salam OM, Omara EA, Mohammed NA, Youness ER, Khadrawy YA, Sleem AA

Drug discoveries & therapeutics1 Dec 2013Cited by 14 (Europe PMC)

PMID24423658 (opens in a new tab)DOI10.5582/ddt.2013.v7.6.261 (opens in a new tab)PepBankPUB-24423658
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin inhibited elevated lipid peroxidation compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin reduced lipid peroxidation compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseLipid peroxidation
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin revealed inhibitory effects on the elevation of lipid peroxidation and nitric oxide induced by LPS.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin inhibited elevated nitric oxide compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin reduced nitric oxide compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseNitric oxide
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Inflammation markers · Whole body
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin revealed inhibitory effects on the elevation of lipid peroxidation and nitric oxide induced by LPS.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin dose-dependently attenuated the decrease in reduced glutathione compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin preserved reduced glutathione compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseReduced glutathione
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    In contrast, the decrease in reduced glutathione level and paraoxonase activity induced by LPS was attenuated by an injection of cerebrolysin in a dose-dependent manner.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin dose-dependently attenuated the decrease in paraoxonase activity compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin preserved paraoxonase activity compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseParaoxonase activity
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    In contrast, the decrease in reduced glutathione level and paraoxonase activity induced by LPS was attenuated by an injection of cerebrolysin in a dose-dependent manner.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin reduced brain NF-κB activation compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin reduced brain NF-κB activation compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBrain NF-kappaB activation
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Moreover, cerebrolysin reduced LPS-induced activation of brain NF-κB and reversed LPS-induced decline of brain butyrylcholinesterase and acetylcholinesterase activities in a dose-dependent manner.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin dose-dependently reversed reduced brain butyrylcholinesterase activity compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin increased brain butyrylcholinesterase activity compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBrain butyrylcholinesterase activity
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Moreover, cerebrolysin reduced LPS-induced activation of brain NF-κB and reversed LPS-induced decline of brain butyrylcholinesterase and acetylcholinesterase activities in a dose-dependent manner.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin dose-dependently reversed reduced brain acetylcholinesterase activity compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin increased brain acetylcholinesterase activity compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBrain acetylcholinesterase activity
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Moreover, cerebrolysin reduced LPS-induced activation of brain NF-κB and reversed LPS-induced decline of brain butyrylcholinesterase and acetylcholinesterase activities in a dose-dependent manner.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-challenged rats, cerebrolysin dose-dependently ameliorated neuronal damage compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin reduced neuronal damage compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseNeuronal damage
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Histopathological analyses revealed that neuronal damage and liver necrosis induced by LPS were ameliorated by cerebrolysin dose-dependently.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-challenged rats, cerebrolysin dose-dependently ameliorated liver necrosis compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin reduced liver necrosis compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseLiver necrosis
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Histopathological analyses revealed that neuronal damage and liver necrosis induced by LPS were ameliorated by cerebrolysin dose-dependently.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin reduced cyclooxygenase 2 expression in cortex or striatum and liver compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin reduced cyclooxygenase 2 expression in brain and liver compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCyclooxygenase 2 expression
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Inflammation markers · Whole body
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin treatment dose-dependently attenuated LPS-induced expressions in cyclooxygenase 2, inducible nitric oxide synthase, and caspase-3 in the cortex or striatum as well as the liver.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin reduced inducible nitric oxide synthase expression in cortex or striatum and liver compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin reduced inducible nitric oxide synthase expression compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseInducible nitric oxide synthase expression
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Inflammation markers · Whole body
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin treatment dose-dependently attenuated LPS-induced expressions in cyclooxygenase 2, inducible nitric oxide synthase, and caspase-3 in the cortex or striatum as well as the liver.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In LPS-challenged rats, cerebrolysin reduced caspase-3 expression in cortex or striatum and liver compared with LPS alone.

    In plain wordsIn rats challenged with LPS, cerebrolysin reduced caspase-3 expression in brain and liver compared with LPS alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCaspase-3 expression
    Study

    ratn: not reported in source

    LPS-induced systemic inflammation
    Comparator
    LPS without cerebrolysin
    Outcome group
    Neuroprotection · Whole body
    Studied dose
    21.5, 43 or 86 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin treatment dose-dependently attenuated LPS-induced expressions in cyclooxygenase 2, inducible nitric oxide synthase, and caspase-3 in the cortex or striatum as well as the liver.
    2 context sentences
    Summary · context
    Rats were intraperitoneally challenged with a single subseptic dose of lipopolysaccharide (LPS; 300 μg/kg) without or with cerebrolysin at doses of 21.5, 43 or 86 mg/kg.
    Summary · context
    After 4 h, rats were euthanized and the brain and liver tissues were subjected to biochemical and histopathological analyses.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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