In young females with vitamin D deficiency, cholecalciferol, calcium or dual supplementation for six months did not change LL‑37 mRNA expression in PBMC versus placebo.
In plain wordsIn young women with low vitamin D, vitamin D or calcium did not change the body's own LL‑37 gene activity, compared with placebo.
- Peptide
- LL-37
- Outcome
- No significant changeLL-37 mRNA expression in PBMC
- Study
n = 131
- Comparator
- Placebo
- Outcome group
- Immune response · Immune and inflammation
Source sentences
Despite significant increase in mean serum 25(OH)D in the cholecalciferol-supplemented groups, their mean mRNA transcripts of LL-37, IFN-γ, IL-4, transcription factors and their IFN-γ/IL-4 and T-bet/GATA-3 ratios were similar to that of calcium and placebo groups.
2 context sentences(design, population, supporting numbers)
Six months of cholecalciferol/calcium supplementation in young females with VDD do not lead to significant alteration in mRNA expression of LL-37, Th1/Th2 cytokines and their transcription factors.
Subjects included 131 females with biochemical VDD randomized to receive (a) oral cholecalciferol (60,000 IU/week for 8 weeks followed by 60,000 IU/fortnight (b) calcium (elemental calcium 500 mg twice/day) (c), dual supplementation and (d) placebo for 6 months.
This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.