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Study · Not a test of the peptide alone · 2013

2 results

[Proteolysis of simple glyprolines by leucine aminopeptidase and enzymes from nasal slime, brain membranes, and rat blood].

Shevchenko KV, V'iunova TV, Nagaev IIu, Andreeva LA, Miasoedov NF

Bioorganicheskaia khimiia1 May 2013Cited by 3 (Europe PMC)

PMID24397030 (opens in a new tab)DOI10.1134/s1068162013030151 (opens in a new tab)PepBankPUB-24397030
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

  1. 01LabNot a test of Semax aloneIn vitro (cell-free)Pharmacokinetics

    In enzyme assays, Pro-Gly-Pro-Leu, Pro-Gly-Pro-Gly and Pro-Gly-Pro were considerably more stable to proteolysis than semax.

    In plain wordsIn lab tests, three simple Pro-Gly-Pro peptides broke down much more slowly than semax in enzyme assays.

    Peptide
    Semax
    Outcome
    Not applicableProteolytic stability of semax compared with simple glyprolines
    Study

    n: not reported in source

    Enzyme proteolysis assays (leucine aminopeptidase, nasal slime, brain membranes, rat blood)
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    It is shown that all three peptides are considerably more stable to proteolysis by N-leucine-aminopeptidase (EC 3.4.11.1, Sigma, type VI, 9.2 units/mg), and by enzymes of nasal slime, brain microsomal fractions, and rat blood.
    1 context sentence
    Summary · context
    Proteolysis of Pro-Gly-Pro-Leu, Pro-Gly-Pro-Gly and Pro-Gly-Pro were studied comparatively to Met-Glu-His-Phe-Pro-Gly-Pro (semax).

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

  2. 02LabNot a test of Semax aloneIn vitro (cell-free)Pharmacokinetics

    In enzyme assays, proteolysis of semax gave His-Phe-Pro-Gly-Pro as the only metabolite.

    In plain wordsIn lab tests, enzymes broke semax down into one fragment only, His-Phe-Pro-Gly-Pro.

    Peptide
    Semax
    Outcome
    Not applicableProteolysis metabolite of semax
    Study

    n: not reported in source

    Enzyme proteolysis assays (leucine aminopeptidase, nasal slime, brain membranes, rat blood)
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Metabolites of the proteolysis showed that semax derives His-Phe-Pro-Gly-Pro only
    1 context sentence
    Summary · context
    Proteolysis of Pro-Gly-Pro-Leu, Pro-Gly-Pro-Gly and Pro-Gly-Pro were studied comparatively to Met-Glu-His-Phe-Pro-Gly-Pro (semax).

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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