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Study · Randomized controlled trial · n = 17 · 2014

4 results

Oxytocin and enhancement of the positive valence of social affiliation memories: an autobiographical memory study.

Cardoso C, Orlando MA, Brown CA, Ellenbogen MA

Social neuroscience6 Jan 2014Cited by 32 (Europe PMC)

PMID24387003 (opens in a new tab)DOI10.1080/17470919.2013.873079 (opens in a new tab)PepBankPUB-24387003
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In male participants, intranasal oxytocin showed a quadratic dose-response curve for autobiographical memory recall.

    In plain wordsIn male participants, the effect of oxytocin on memory recall followed a curved dose pattern, not a straight line.

    Peptide
    Oxytocin
    Outcome
    MixedQuadratic dose-response of autobiographical memory recall
    Study

    n = 17

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU and 48 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Analyses revealed a quadratic dose-response curve for the effects of intranasal oxytocin on autobiographical memory recall.
    1 context sentence
    Summary · context
    Seventeen male participants self-administered a placebo or oxytocin (24 IU, 48 IU) using a nasal spray on three separate occasions in a placebo-controlled, double-blind, and within-subject experiment.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male participants, the 24 IU dose of intranasal oxytocin increased the number of specific personal memories recalled relative to the 48 IU dose and placebo.

    In plain wordsIn male participants, the 24 IU oxytocin dose helped recall of more specific personal memories than the 48 IU dose or placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseNumber of specific personal memories recalled (24 IU)
    Study

    n = 17

    Comparator
    Oxytocin 48 IU and placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    The 24 IU dose, relative to the 48 IU dose and placebo, increased the number of specific personal memories recalled and promoted the recall of social affiliation memories that were rated more positively.
    1 context sentence
    Summary · context
    Seventeen male participants self-administered a placebo or oxytocin (24 IU, 48 IU) using a nasal spray on three separate occasions in a placebo-controlled, double-blind, and within-subject experiment.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In male participants, the 24 IU dose of intranasal oxytocin promoted the recall of social affiliation memories that were rated more positively, relative to the 48 IU dose and placebo.

    In plain wordsIn male participants, the 24 IU oxytocin dose led to more recall of positive social memories than the 48 IU dose or placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseRecall of positively rated social affiliation memories (24 IU)
    Study

    n = 17

    Comparator
    Oxytocin 48 IU and placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    The 24 IU dose, relative to the 48 IU dose and placebo, increased the number of specific personal memories recalled and promoted the recall of social affiliation memories that were rated more positively.
    1 context sentence
    Summary · context
    Seventeen male participants self-administered a placebo or oxytocin (24 IU, 48 IU) using a nasal spray on three separate occasions in a placebo-controlled, double-blind, and within-subject experiment.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In male participants, the 48 IU dose of intranasal oxytocin had no effect on autobiographical memory recall.

    In plain wordsIn male participants, the higher 48 IU oxytocin dose did not change memory recall.

    Peptide
    Oxytocin
    Outcome
    No significant changeAutobiographical memory recall at 48 IU
    Study

    n = 17

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    48 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    The lack of effect with the 48 IU dose could be due to saturation of the oxytocin receptors at higher doses.
    1 context sentence
    Summary · context
    Seventeen male participants self-administered a placebo or oxytocin (24 IU, 48 IU) using a nasal spray on three separate occasions in a placebo-controlled, double-blind, and within-subject experiment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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