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Study · Measured the body's own peptide · 2014

5 results

Positive correlations between hCAP18/LL-37 and chondroitin sulphate levels in chronic periodontitis.

Makeudom A, Kulpawaropas S, Montreekachon P, Khongkhunthian S, Sastraruji T, Pothacharoen P, Kongtawelert P, Krisanaprakornkit S

Journal of clinical periodontology25 Dec 2013Cited by 8 (Europe PMC)

PMID24372543 (opens in a new tab)DOI10.1111/jcpe.12216 (opens in a new tab)PepBankPUB-24372543
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with periodontal disease, gingival crevicular fluid hCAP18/LL‑37 levels were higher in aggressive and chronic periodontitis than in gingivitis and healthy groups.

    In plain wordsPatients with periodontitis had higher levels of the body's own hCAP18/LL‑37 in gum fluid than healthy people or people with gingivitis.

    Peptide
    LL-37
    Outcome
    IncreasehCAP18/LL-37 level in gingival crevicular fluid
    Study

    n = 76

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    The median levels of hCAP18/LL-37 in the aggressive and the chronic periodontitis (CP) groups were significantly greater than those in the gingivitis and the healthy groups (p < 0.05).
    1 context sentence
    Summary · context
    Gingival crevicular fluid samples from 51 patients and 25 healthy volunteers were analysed for the hCAP18/LL-37 levels by immunoblotting and were determined for the CS levels by the competitive enzyme-linked immunosorbent assay.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In chronic periodontitis, the unprocessed 18-kDa hCAP18/LL‑37 fragment correlated positively with chondroitin sulphate levels in gingival crevicular fluid.

    In plain wordsIn people with chronic periodontitis, the body's own unprocessed 18-kDa fragment rose and fell together with chondroitin sulphate levels.

    Peptide
    LL-37
    Outcome
    IncreaseCorrelation of 18-kDa hCAP18 fragment with chondroitin sulphate in chronic periodontitis
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation

    Measurements

    correlation r
    0.65 r
    18-kDa fragment vs CS, chronic periodontitis

    Source sentences

    Summary
    Significant correlations between the unprocessed 18-kDa fragment and CS levels (r = 0.650; p < 0.001) and between the mature 4.6-kDa fragment and CS levels (r = 0.502; p < 0.001) were observed only in the CP group.
    1 context sentence
    Summary · context
    Gingival crevicular fluid samples from 51 patients and 25 healthy volunteers were analysed for the hCAP18/LL-37 levels by immunoblotting and were determined for the CS levels by the competitive enzyme-linked immunosorbent assay.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In chronic periodontitis, the mature 4.6-kDa LL‑37 fragment correlated positively with chondroitin sulphate levels in gingival crevicular fluid.

    In plain wordsIn people with chronic periodontitis, the body's own mature 4.6-kDa fragment rose and fell together with chondroitin sulphate levels.

    Peptide
    LL-37
    Outcome
    IncreaseCorrelation of mature 4.6-kDa LL-37 fragment with chondroitin sulphate in chronic periodontitis
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation

    Measurements

    correlation r
    0.502 r
    4.6-kDa fragment vs CS, chronic periodontitis

    Source sentences

    Summary
    Significant correlations between the unprocessed 18-kDa fragment and CS levels (r = 0.650; p < 0.001) and between the mature 4.6-kDa fragment and CS levels (r = 0.502; p < 0.001) were observed only in the CP group.
    1 context sentence
    Summary · context
    Gingival crevicular fluid samples from 51 patients and 25 healthy volunteers were analysed for the hCAP18/LL-37 levels by immunoblotting and were determined for the CS levels by the competitive enzyme-linked immunosorbent assay.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In aggressive periodontitis, hCAP18/LL‑37 levels did not correlate with chondroitin sulphate levels, unlike in chronic periodontitis.

    In plain wordsIn aggressive periodontitis, the body's own hCAP18/LL‑37 levels did not track chondroitin sulphate levels, unlike in chronic periodontitis.

    Peptide
    LL-37
    Outcome
    No significant changeCorrelation of hCAP18/LL-37 with chondroitin sulphate in aggressive periodontitis
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    The significant correlations between the hCAP18/LL-37 and the CS levels were found in CP, but not in aggressive periodontitis.
    1 context sentence
    Summary · context
    Gingival crevicular fluid samples from 51 patients and 25 healthy volunteers were analysed for the hCAP18/LL-37 levels by immunoblotting and were determined for the CS levels by the competitive enzyme-linked immunosorbent assay.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LL-37.

  1. 05HumanNot a test of LL-37 aloneObservational studyOther

    Tris buffer at pH 9.85 recovered about 70% of hCAP18/LL‑37 from Periopaper strips in a sample-handling method.

    In plain wordsA buffer recovered about 70% of the body's own hCAP18/LL‑37 from sampling strips in this lab method.

    Peptide
    LL-37
    Outcome
    Not applicableRecovery of hCAP18/LL-37 from Periopaper strips with Tris buffer
    Study

    n: not reported in source

    Outcome group
    Analytical methods and detection · Pharmacology

    Measurements

    recovery
    ≈ 70%
    Tris buffer pH 9.85, Periopaper strips

    Source sentences

    Summary
    Tris buffer pH 9.85 was selected to recover hCAP18/LL-37 from Periopaper strips, in which the percentages of recovery were around 70%.
    1 context sentence
    Summary · context
    Gingival crevicular fluid samples from 51 patients and 25 healthy volunteers were analysed for the hCAP18/LL-37 levels by immunoblotting and were determined for the CS levels by the competitive enzyme-linked immunosorbent assay.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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