Assessing the optimal dose for Cetrorelix in Chinese women undergoing ovarian stimulation during the course of IVF-ET treatment.

Lai Q, Hu J, Zeng D, Hu J, Cai F, Yang F, Chen C, He X, Yang P, Yu Q, Zhang S, Xu JF, Wang CY, Wang CY

American journal of translational research1 Dec 2013Cited by 1 (Europe PMC)

PMID24349624PMCIDPMC3853427PepBankPUB-24349624

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanRandomized controlled trialEfficacy outcome
In Chinese women undergoing ovarian stimulation, the lower cetrorelix dose had a lower cancellation rate than the higher dose.
In plain wordsIn Chinese women undergoing ovarian stimulation, the lower cetrorelix dose had a lower cancellation rate than the higher dose.
Peptide
Cetrorelix
Outcome
DecreaseCycle cancellation rate
Study
n = 87
Comparator
0.25 mg daily cetrorelix
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.125 mg daily · injectionAs given in this study (human).
Source sentences
Summary
In general, a daily dose of 0.125 mg cetrorelix could be more optimal for Chinese women as manifested by the lower cancellation rate, higher implantation rate and clinical pregnancy rate.
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted a prospective, randomized, and controlled trial to assess the optimal dose for GnRH antagonist, cetrorelix, for Chinese women during the course of ovarian stimulation.
Summary · context
The patients were randomly divided into two groups, in which 48 patients were advised to inject 0.25 mg Cetrorelix daily (the 0.25 mg group), while 39 patients were instructed to receive a daily dose of 0.125 mg cetrorelix (the 0.125 mg group).
Report a problemFND-2434962401
02HumanRandomized controlled trialEfficacy outcome
In Chinese women undergoing ovarian stimulation, the lower cetrorelix dose had a higher implantation rate than the higher dose.
In plain wordsIn Chinese women undergoing ovarian stimulation, the lower cetrorelix dose had a higher implantation rate than the higher dose.
Peptide
Cetrorelix
Outcome
IncreaseImplantation rate
Study
n = 87
Comparator
0.25 mg daily cetrorelix
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.125 mg daily · injectionAs given in this study (human).
Source sentences
Summary
In general, a daily dose of 0.125 mg cetrorelix could be more optimal for Chinese women as manifested by the lower cancellation rate, higher implantation rate and clinical pregnancy rate.
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted a prospective, randomized, and controlled trial to assess the optimal dose for GnRH antagonist, cetrorelix, for Chinese women during the course of ovarian stimulation.
Summary · context
The patients were randomly divided into two groups, in which 48 patients were advised to inject 0.25 mg Cetrorelix daily (the 0.25 mg group), while 39 patients were instructed to receive a daily dose of 0.125 mg cetrorelix (the 0.125 mg group).
Report a problemFND-2434962402
03HumanRandomized controlled trialEfficacy outcome
In Chinese women undergoing ovarian stimulation, the lower cetrorelix dose had a higher clinical pregnancy rate than the higher dose.
In plain wordsIn Chinese women undergoing ovarian stimulation, the lower cetrorelix dose had a higher pregnancy rate than the higher dose.
Peptide
Cetrorelix
Outcome
IncreaseClinical pregnancy rate
Study
n = 87
Comparator
0.25 mg daily cetrorelix
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.125 mg daily · injectionAs given in this study (human).
Source sentences
Summary
In general, a daily dose of 0.125 mg cetrorelix could be more optimal for Chinese women as manifested by the lower cancellation rate, higher implantation rate and clinical pregnancy rate.
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted a prospective, randomized, and controlled trial to assess the optimal dose for GnRH antagonist, cetrorelix, for Chinese women during the course of ovarian stimulation.
Summary · context
The patients were randomly divided into two groups, in which 48 patients were advised to inject 0.25 mg Cetrorelix daily (the 0.25 mg group), while 39 patients were instructed to receive a daily dose of 0.125 mg cetrorelix (the 0.125 mg group).
Report a problemFND-2434962403
04HumanObservational studyEfficacy outcome
In Chinese patients receiving cetrorelix 0.125 mg daily, age under 35 was associated with 3-fold higher implantation rates than age ≥35.
In plain wordsWith cetrorelix 0.125 mg daily, age under 35 was linked to 3-fold higher implantation rates than age ≥35.
Peptide
Cetrorelix
Outcome
IncreaseImplantation rate by age
Study
n: not reported in source
Comparator
Patients aged ≥35 years receiving the same dose
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.125 mg daily · injectionAs given in this study (human).
Measurements
Implantation rate ratio
3 fold
under 35 versus ≥35 years
Source sentences
Summary
Specifically, daily administration of 0.125 mg cetrorelix for patients under 35 years old is associated with a 3-fold higher implantation rate and a 5-fold higher clinical pregnancy rate as compared with that of those patients ≥ 35 years old.
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted a prospective, randomized, and controlled trial to assess the optimal dose for GnRH antagonist, cetrorelix, for Chinese women during the course of ovarian stimulation.
Summary · context
The patients were randomly divided into two groups, in which 48 patients were advised to inject 0.25 mg Cetrorelix daily (the 0.25 mg group), while 39 patients were instructed to receive a daily dose of 0.125 mg cetrorelix (the 0.125 mg group).
Report a problemFND-2434962404
05HumanObservational studyEfficacy outcome
In Chinese patients receiving cetrorelix 0.125 mg daily, age under 35 was associated with 5-fold higher clinical pregnancy rates than age ≥35.
In plain wordsWith cetrorelix 0.125 mg daily, age under 35 was linked to 5-fold higher clinical pregnancy rates than age ≥35.
Peptide
Cetrorelix
Outcome
IncreaseClinical pregnancy rate by age
Study
n: not reported in source
Comparator
Patients aged ≥35 years receiving the same dose
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.125 mg daily · injectionAs given in this study (human).
Measurements
Clinical pregnancy rate ratio
5 fold
under 35 versus ≥35 years
Source sentences
Summary
Specifically, daily administration of 0.125 mg cetrorelix for patients under 35 years old is associated with a 3-fold higher implantation rate and a 5-fold higher clinical pregnancy rate as compared with that of those patients ≥ 35 years old.
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted a prospective, randomized, and controlled trial to assess the optimal dose for GnRH antagonist, cetrorelix, for Chinese women during the course of ovarian stimulation.
Summary · context
The patients were randomly divided into two groups, in which 48 patients were advised to inject 0.25 mg Cetrorelix daily (the 0.25 mg group), while 39 patients were instructed to receive a daily dose of 0.125 mg cetrorelix (the 0.125 mg group).
Report a problemFND-2434962405
06HumanObservational studyEfficacy outcome
In Chinese patients receiving cetrorelix 0.25 mg daily, age ≥35 was associated with higher implantation rates than age <35.
In plain wordsWith cetrorelix 0.25 mg daily, age ≥35 was linked to higher implantation rates than age <35.
Peptide
Cetrorelix
Outcome
IncreaseImplantation rate by age
Study
n: not reported in source
Comparator
Patients aged <35 years receiving the same dose
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.25 mg daily · injectionAs given in this study (human).
Source sentences
Summary
On the contrary, higher rates for implantation and clinical pregnancy were noted by daily injection of 0.25 mg cetrorelix in elder patients (≥ 35 years old) as compared with that of young patients (< 35 years old).
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted a prospective, randomized, and controlled trial to assess the optimal dose for GnRH antagonist, cetrorelix, for Chinese women during the course of ovarian stimulation.
Summary · context
The patients were randomly divided into two groups, in which 48 patients were advised to inject 0.25 mg Cetrorelix daily (the 0.25 mg group), while 39 patients were instructed to receive a daily dose of 0.125 mg cetrorelix (the 0.125 mg group).
Report a problemFND-2434962406
07HumanObservational studyEfficacy outcome
In Chinese patients receiving cetrorelix 0.25 mg daily, age ≥35 was associated with higher clinical pregnancy rates than age <35.
In plain wordsWith cetrorelix 0.25 mg daily, age ≥35 was linked to higher clinical pregnancy rates than age <35.
Peptide
Cetrorelix
Outcome
IncreaseClinical pregnancy rate by age
Study
n: not reported in source
Comparator
Patients aged <35 years receiving the same dose
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.25 mg daily · injectionAs given in this study (human).
Source sentences
Summary
On the contrary, higher rates for implantation and clinical pregnancy were noted by daily injection of 0.25 mg cetrorelix in elder patients (≥ 35 years old) as compared with that of young patients (< 35 years old).
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted a prospective, randomized, and controlled trial to assess the optimal dose for GnRH antagonist, cetrorelix, for Chinese women during the course of ovarian stimulation.
Summary · context
The patients were randomly divided into two groups, in which 48 patients were advised to inject 0.25 mg Cetrorelix daily (the 0.25 mg group), while 39 patients were instructed to receive a daily dose of 0.125 mg cetrorelix (the 0.125 mg group).
Report a problemFND-2434962407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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