Mechano growth factor E peptide regulates migration and differentiation of bone marrow mesenchymal stem cells.

Cui H, Yi Q, Feng J, Yang L, Tang L

Journal of molecular endocrinology30 Jan 2014Cited by 28 (Europe PMC)

PMID24323763DOI10.1530/jme-13-0157PepBankPUB-24323763

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In rat bone marrow mesenchymal stem cells, MGF E peptide had no effect on proliferation.
In plain wordsIn rat stem cells in a lab dish, MGF E peptide did not change how fast the cells multiplied.
Peptide
MGF / PEG-MGF
Outcome
No significant changeBMSC proliferation
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells (rBMSCs)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Our results revealed that treatment with MGF E peptide had no effect on BMSC proliferation.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of MGF E peptide on rat BMSCs (rBMSCs).
Report a problemFND-2432376301
02LabIn vitro (cells)Activity measurement
In rat bone marrow mesenchymal stem cells, MGF E peptide significantly enhanced migration in wound-healing and transwell assays.
In plain wordsIn rat stem cells in a lab dish, MGF E peptide made the cells move more.
Peptide
MGF / PEG-MGF
Outcome
IncreaseBMSC migration
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells (rBMSCs)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
However, both wound-healing and transwell assays indicated that MGF E peptide could significantly enhance rBMSCs migration ability.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of MGF E peptide on rat BMSCs (rBMSCs).
Report a problemFND-2432376302
03LabIn vitro (cells)Mechanism
In rat bone marrow mesenchymal stem cells, MGF E peptide reduced the expression of osteogenic genes.
In plain wordsIn rat stem cells in a lab dish, MGF E peptide lowered the activity of genes for bone formation.
Peptide
MGF / PEG-MGF
Outcome
DecreaseOsteogenic gene expression
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells (rBMSCs)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
MGF E peptide also reduced the expression levels of osteogenic genes
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of MGF E peptide on rat BMSCs (rBMSCs).
Report a problemFND-2432376303
04LabIn vitro (cells)Mechanism
In rat bone marrow mesenchymal stem cells, MGF E peptide increased the expression of adipogenic genes.
In plain wordsIn rat stem cells in a lab dish, MGF E peptide raised the activity of genes for fat cell formation.
Peptide
MGF / PEG-MGF
Outcome
IncreaseAdipogenic gene expression
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells (rBMSCs)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
but increased the expression levels of adipogenic genes
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of MGF E peptide on rat BMSCs (rBMSCs).
Report a problemFND-2432376304
05LabIn vitro (cells)Mechanism
In rat bone marrow mesenchymal stem cells, MGF E peptide activated phosphorylation of Erk1/2.
In plain wordsIn rat stem cells in a lab dish, MGF E peptide switched on the Erk1/2 signal.
Peptide
MGF / PEG-MGF
Outcome
IncreaseErk1/2 phosphorylation
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells (rBMSCs)
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
phosphorylation-Erk1/2 was activated by MGF E peptide
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of MGF E peptide on rat BMSCs (rBMSCs).
Report a problemFND-2432376305

Studies that did not test the peptide alone1

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

06LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism
In rat bone marrow mesenchymal stem cells, blocking Erk1/2 or the IGF1 receptor repressed the migration effect of MGF E peptide.
In plain wordsIn rat stem cells in a lab dish, blocking Erk1/2 or the IGF1 receptor reduced the extra movement caused by MGF E peptide.
Peptide
MGF / PEG-MGF
Outcome
DecreaseMigration after Erk1/2 or IGF1 receptor blockade
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells (rBMSCs)
Outcome group
Receptor activity and mechanism · Musculoskeletal
Source sentences
Summary
blockage of either Erk1/2 or IGF1 receptor could repress the migration effect of MGF E peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of MGF E peptide on rat BMSCs (rBMSCs).
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2432376306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.