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Study · Animal study (in vivo) · mouse · 2014

4 results

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.

Kolomin T, Morozova M, Volkova A, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N

Molecular immunology27 Nov 2013Cited by 3 (Europe PMC)

PMID24291245 (opens in a new tab)DOI10.1016/j.molimm.2013.11.002 (opens in a new tab)PepBankPUB-24291245
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mouse spleen, Selank caused a significant 3-fold decrease in C3 mRNA level 30 min after injection.

    In plain wordsIn mice, Selank lowered the activity of the immune gene C3 in the spleen within 30 minutes.

    Peptide
    Selank
    Outcome
    DecreaseC3 mRNA level in spleen
    Study

    mousen: not reported in source

    Mouse spleen, real-time PCR
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 μg/kg · intraperitoneal · single injectionAs given in this study (mouse).

    Measurements

    C3 mRNA decrease
    3-fold
    30 min after Selank

    Source sentences

    Summary
    We found a significant 3-fold decrease in the C3 mRNA level just 30 min after Selank injection
    1 context sentence
    Summary · context
    In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 μg/kg) of peptides using real-time PCR method.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mouse spleen, Selank caused a wave-like alteration in Casp1 mRNA level over time.

    In plain wordsIn mice, Selank made the activity of the Casp1 gene in the spleen rise and fall over time.

    Peptide
    Selank
    Outcome
    MixedCasp1 mRNA level in spleen over time
    Study

    mousen: not reported in source

    Mouse spleen, real-time PCR
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 μg/kg · intraperitoneal · single injectionAs given in this study (mouse).

    Source sentences

    Summary
    A wave-like alteration in the Casp1 mRNA level was observed after Selank injection.
    1 context sentence
    Summary · context
    In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 μg/kg) of peptides using real-time PCR method.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mouse spleen, Selank caused a significant alteration in Il2rg mRNA level at early time points.

    In plain wordsIn mice, Selank changed the activity of the Il2rg gene in the spleen at early time points.

    Peptide
    Selank
    Outcome
    MixedIl2rg mRNA level in spleen
    Study

    mousen: not reported in source

    Mouse spleen, real-time PCR
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 μg/kg · intraperitoneal · single injectionAs given in this study (mouse).

    Source sentences

    Summary
    We found a significant alteration in the mRNA level of the Il2rg gene at early time points after Selank and Gly-Pro administration
    1 context sentence
    Summary · context
    In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 μg/kg) of peptides using real-time PCR method.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mouse spleen, Selank reduced Xcr1 mRNA level 90 min after administration.

    In plain wordsIn mice, Selank lowered the activity of the Xcr1 gene in the spleen after 90 minutes.

    Peptide
    Selank
    Outcome
    DecreaseXcr1 mRNA level in spleen
    Study

    mousen: not reported in source

    Mouse spleen, real-time PCR
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 μg/kg · intraperitoneal · single injectionAs given in this study (mouse).

    Source sentences

    Summary
    an almost equal reduction in the Xcr1 mRNA level 90 min after the administration of Selank and its fragment.
    1 context sentence
    Summary · context
    In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 μg/kg) of peptides using real-time PCR method.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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