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Study · Measured the body's own peptide · 2014

3 results

Effect of growth hormone on aging connective tissue in muscle and tendon: gene expression, morphology, and function following immobilization and rehabilitation.

Boesen AP, Dideriksen K, Couppé C, Magnusson SP, Schjerling P, Boesen M, Aagaard P, Kjaer M, Langberg H

Journal of applied physiology (Bethesda, Md. : 1985)14 Nov 2013Cited by 31 (Europe PMC)

PMID24235105 (opens in a new tab)DOI10.1152/japplphysiol.01077.2013 (opens in a new tab)PepBankPUB-24235105
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In elderly men, IGF-1Ea/Ec mRNA expression in muscle showed a time and a group effect, with a difference between growth hormone and placebo.

    In plain wordsIn older men, the body's own IGF-1Ea/Ec gene activity in muscle differed between the growth hormone group and the placebo group.

    Peptide
    MGF / PEG-MGF
    Outcome
    Direction not reportedIGF-1Ea/Ec mRNA expression in muscle, GH versus placebo
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    Both a time and a group effect were seen for IGF-1Ea/Ec and COL1A1/3A1 mRNA expression in muscle, with a difference between GH and Plc.
    1 context sentence
    Summary · context
    Elderly men (65-75 yr; n = 12) had one leg immobilized 2 wk followed by 6 wk of retraining and were randomly assigned to daily injections of recombinant GH (rhGH; n = 6) or placebo (Plc; n = 6).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In elderly men given daily recombinant growth hormone, IGF-1Ea/Ec mRNA expression in muscle increased following immobilization and retraining.

    In plain wordsIn older men given growth hormone, the body's own IGF-1Ea/Ec gene activity in muscle rose after immobilization and retraining.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-1Ea/Ec mRNA expression in muscle, GH group
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    IGF-1Ea/Ec and COL-1A1/3A1 mRNA expression increased in muscle following immobilization and retraining in subjects receiving GH
    1 context sentence
    Summary · context
    Elderly men (65-75 yr; n = 12) had one leg immobilized 2 wk followed by 6 wk of retraining and were randomly assigned to daily injections of recombinant GH (rhGH; n = 6) or placebo (Plc; n = 6).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelRandomized controlled trialOther

    In elderly men given placebo, IGF-1Ec mRNA expression in muscle increased only after retraining.

    In plain wordsIn older men given placebo, the body's own IGF-1Ec gene activity in muscle rose only after retraining.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-1Ec mRNA expression in muscle, placebo group
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    an increase in IGF-1Ec mRNA expression was seen in the Plc group only after retraining.
    1 context sentence
    Summary · context
    Elderly men (65-75 yr; n = 12) had one leg immobilized 2 wk followed by 6 wk of retraining and were randomly assigned to daily injections of recombinant GH (rhGH; n = 6) or placebo (Plc; n = 6).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)

WithdrawnPhase 2NCT02597660

A Study to Evaluate the Efficacy of Somatropin in the Treatment of Patellar Tendinopathy

Hospital for Special Surgery, New Yorkn = 01 May 2020 to 1 Dec 2020

Tendinopathy

Trial pageClinicalTrials.govUpdated 31 Mar 2022

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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