Insulin-like growth factor I (IGF-1) Ec/Mechano Growth factor--a splice variant of IGF-1 within the growth plate.

Schlegel W, Raimann A, Halbauer D, Scharmer D, Sagmeister S, Wessner B, Helmreich M, Haeusler G, Egerbacher M

PloS one11 Oct 2013Cited by 19 (Europe PMC)

PMID24146828PMCIDPMC3795771DOI10.1371/journal.pone.0076133PepBankPUB-24146828

Summary

Human insulin-like growth factor 1 Ec (IGF-1Ec), also called mechano growth factor (MGF), is a splice variant of insulin-like growth factor 1 (IGF-1), which has been shown in vitro as well as in vivo to induce growth and hypertrophy in mechanically stimulated or damaged muscle. Growth, hypertrophy and responses to mechanical stimulation are important reactions of cartilaginous tissues, especially those in growth plates. Therefore, we wanted to ascertain if MGF is expressed in growth plate cartilage and if it influences proliferation of chondrocytes, as it does in musculoskeletal tissues. MGF expression was analyzed in growth plate and control tissue samples from piglets aged 3 to 6 weeks. Furthermore, growth plate chondrocyte cell culture was used to evaluate the effects of the MGF peptide on proliferation. We showed that MGF is expressed in considerable amounts in the tissues evaluated. We found the MGF peptide to be primarily located in the cytoplasm, and in some instances, it was also found in the nucleus of the cells. Addition of MGF peptides was not associated with growth plate chondrocyte proliferation.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In growth plate chondrocyte culture, addition of MGF peptides was not associated with chondrocyte proliferation.
In plain wordsIn cells, adding MGF peptides did not make pig growth plate cartilage cells multiply.
Peptide
MGF / PEG-MGF
Outcome
No significant changeChondrocyte proliferation
Study
pign: not reported in source
Growth plate chondrocyte cell culture
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, growth plate chondrocyte cell culture was used to evaluate the effects of the MGF peptide on proliferation.
1 context sentence(design, population, supporting numbers)
Summary · context
Addition of MGF peptides was not associated with growth plate chondrocyte proliferation.
Show in the study text Report a problemFND-2414682803

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

02LabEndogenous levelEx vivo tissueOther
In piglets aged 3 to 6 weeks, MGF was expressed in considerable amounts in growth plate and control tissue.
In plain wordsIn young pigs, the body's own MGF was found in large amounts in growth plate tissue.
Peptide
MGF / PEG-MGF
Outcome
Not applicableMGF expression in growth plate tissue
Study
pign: not reported in source
Growth plate and control tissue from piglets aged 3 to 6 weeks
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
MGF expression was analyzed in growth plate and control tissue samples from piglets aged 3 to 6 weeks.
1 context sentence(design, population, supporting numbers)
Summary · context
We showed that MGF is expressed in considerable amounts in the tissues evaluated.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-2414682801
03LabEndogenous levelEx vivo tissueMechanism
In growth plate tissue, the MGF peptide was found mainly in the cytoplasm and sometimes in the nucleus of cells.
In plain wordsIn young pig tissue, natural MGF was mostly inside the cell body and sometimes in the nucleus.
Peptide
MGF / PEG-MGF
Outcome
Not applicableSubcellular location of MGF peptide
Study
pign: not reported in source
Growth plate tissue samples from piglets
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
We found the MGF peptide to be primarily located in the cytoplasm, and in some instances, it was also found in the nucleus of the cells.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-2414682802

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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