Mechano-growth factor induces migration of rat mesenchymal stem cells by altering its mechanical properties and activating ERK pathway.

Wu J, Wu K, Lin F, Luo Q, Yang L, Shi Y, Song G, Sung KL

Biochemical and biophysical research communications16 Oct 2013Cited by 18 (Europe PMC)

PMID24140053DOI10.1016/j.bbrc.2013.10.031PepBankPUB-24140053

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In rat mesenchymal stem cells, MGF increased migration in a concentration-dependent manner.
In plain wordsIn cells, MGF made rat stem cells move more, and more MGF gave more movement.
Peptide
MGF / PEG-MGF
Outcome
IncreaserMSC migration
Study
ratn: not reported in source
Rat mesenchymal stem cells
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In the present study, MGF motivated migration of rat MSCs (rMSCs) in a concentration-dependent manner and optimal concentration of MGF at 50 ng/mL (defined as MGF treatment in this paper) was demonstrated.
Report a problemFND-2414005301
02LabIn vitro (cells)Efficacy outcome
In rat mesenchymal stem cells, 50 ng/mL was the optimal MGF concentration for migration.
In plain wordsIn cells, 50 ng/mL of MGF worked best to make rat stem cells move.
Peptide
MGF / PEG-MGF
Outcome
Not applicableOptimal MGF concentration for rMSC migration
Study
ratn: not reported in source
Rat mesenchymal stem cells
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
50 ng/mLAs given in this study (rat).
Measurements
Optimal concentration
50 ng/mL
rMSC migration
Source sentences
Summary
optimal concentration of MGF at 50 ng/mL (defined as MGF treatment in this paper) was demonstrated
Report a problemFND-2414005302
03LabIn vitro (cells)Mechanism
In rat mesenchymal stem cells, MGF treatment enhanced cell traction force.
In plain wordsIn cells, MGF raised the pulling force that rat stem cells use to move.
Peptide
MGF / PEG-MGF
Outcome
IncreaseCell traction force
Study
ratn: not reported in source
Rat mesenchymal stem cells
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
50 ng/mLAs given in this study (rat).
Source sentences
Summary
Notably, enhancement of mechanical properties that is pertinent to cell migration, such as cell traction force and cell stiffness were found to respond to MGF treatment.
Report a problemFND-2414005303
04LabIn vitro (cells)Mechanism
In rat mesenchymal stem cells, MGF treatment enhanced cell stiffness.
In plain wordsIn cells, MGF made rat stem cells stiffer.
Peptide
MGF / PEG-MGF
Outcome
IncreaseCell stiffness
Study
ratn: not reported in source
Rat mesenchymal stem cells
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
50 ng/mLAs given in this study (rat).
Source sentences
Summary
Notably, enhancement of mechanical properties that is pertinent to cell migration, such as cell traction force and cell stiffness were found to respond to MGF treatment.
Report a problemFND-2414005304
05LabIn vitro (cells)Mechanism
In rat mesenchymal stem cells, MGF increased phosphorylation of ERK.
In plain wordsIn cells, MGF switched on the ERK signal in rat stem cells.
Peptide
MGF / PEG-MGF
Outcome
IncreaseERK phosphorylation
Study
ratn: not reported in source
Rat mesenchymal stem cells
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
50 ng/mLAs given in this study (rat).
Source sentences
Summary
Furthermore, MGF increased phosphorylation of extracellular signal-regulated kinase (ERK)
Report a problemFND-2414005305

Studies that did not test the peptide alone1

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

06LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism
In rat mesenchymal stem cells, the ERK inhibitor PD98059 suppressed ERK phosphorylation and abolished MGF-induced migration.
In plain wordsIn cells, blocking ERK stopped MGF from making rat stem cells move, which shows ERK is part of the pathway.
Peptide
MGF / PEG-MGF
Outcome
DecreaseERK inhibitor effect on MGF-induced migration
Study
ratn: not reported in source
Rat mesenchymal stem cells
Comparator
MGF alone
Outcome group
Receptor activity and mechanism · Musculoskeletal
Source sentences
Summary
ERK inhibitor (i.e., PD98059) suppressed ERK phosphorylation, and abolished MGF-induced rMSC migration were found, demonstrating that ERK is involved molecule for MGF-induced rMSC migration.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2414005306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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