Anxiolytic activity of dipeptide GB-115 after oral administration.

Kolik LG, Konstantinopolsky MA, Ryibina IV, Povarnina PY, Gudasheva TA, Seredenin SB

Bulletin of experimental biology and medicine1 Jun 2013Cited by 1 (Europe PMC)

PMID24130989DOI10.1007/s10517-013-2112-6PepBankPUB-24130989

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In outbred mice, oral GB‑115 showed an anxiolytic effect in the open field test.
In plain wordsIn mice, oral GB‑115 reduced anxiety in the open field test.
Peptide
GB-115
Outcome
DecreaseOpen field anxiety
Study
mousen: not reported in source
Outbred mice, open field test
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.1-0.5 mg/kg · oralAs given in this study (mouse).
Source sentences
Summary
The anxiolytic effect of talanax was observed in outbred mice (0.1-0.5 mg/kg) and in inbred BALB/c mice (0.1 and 5.0 mg/kg) in the open field test.
1 context sentence(design, population, supporting numbers)
Summary · context
The anxiolytic effects of GB-115, a retroanalogue of cholecystokinin-4, administered orally to outbred and inbred animals with different level of emotionality, were studied in the open field test and elevated plus-maze test.
Report a problemFND-2413098901
02AnimalAnimal study (in vivo)Efficacy outcome
In BALB/c mice, oral GB‑115 showed an anxiolytic effect in the open field test.
In plain wordsIn mice, oral GB‑115 reduced anxiety in the open field test.
Peptide
GB-115
Outcome
DecreaseOpen field anxiety
Study
mousen: not reported in source
BALB/c mice, open field test
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.1 and 5.0 mg/kg · oralAs given in this study (mouse).
Source sentences
Summary
The anxiolytic effect of talanax was observed in outbred mice (0.1-0.5 mg/kg) and in inbred BALB/c mice (0.1 and 5.0 mg/kg) in the open field test.
1 context sentence(design, population, supporting numbers)
Summary · context
The anxiolytic effects of GB-115, a retroanalogue of cholecystokinin-4, administered orally to outbred and inbred animals with different level of emotionality, were studied in the open field test and elevated plus-maze test.
Report a problemFND-2413098902
03AnimalAnimal study (in vivo)Efficacy outcome
In outbred rats, GB‑115 increased the time of entries into open arms.
In plain wordsIn rats, GB‑115 increased the time of entries into open maze arms.
Peptide
GB-115
Outcome
IncreaseTime of entries into open arms
Study
ratn: not reported in source
Outbred rats, elevated plus-maze
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.5-0.7 mg/kg · oralAs given in this study (rat).
Source sentences
Summary
GB-115 increased the time of entries into open arms in outbred rats (0.5-0.7 mg/kg) and in BALB/c mice (0.1 mg/kg).
1 context sentence(design, population, supporting numbers)
Summary · context
The anxiolytic effects of GB-115, a retroanalogue of cholecystokinin-4, administered orally to outbred and inbred animals with different level of emotionality, were studied in the open field test and elevated plus-maze test.
Report a problemFND-2413098903
04AnimalAnimal study (in vivo)Efficacy outcome
In BALB/c mice, GB‑115 increased the time of entries into open arms.
In plain wordsIn mice, GB‑115 increased the time of entries into open maze arms.
Peptide
GB-115
Outcome
IncreaseTime of entries into open arms
Study
mousen: not reported in source
BALB/c mice, elevated plus-maze
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.1 mg/kg · oralAs given in this study (mouse).
Source sentences
Summary
GB-115 increased the time of entries into open arms in outbred rats (0.5-0.7 mg/kg) and in BALB/c mice (0.1 mg/kg).
1 context sentence(design, population, supporting numbers)
Summary · context
The anxiolytic effects of GB-115, a retroanalogue of cholecystokinin-4, administered orally to outbred and inbred animals with different level of emotionality, were studied in the open field test and elevated plus-maze test.
Report a problemFND-2413098904
05AnimalAnimal study (in vivo)Efficacy outcome
In animals, reported anxiolytic doses shifted from 0.006-0.100 mg/kg intraperitoneally to 0.1-5.0 mg/kg orally.
In plain wordsIn animals, reported GB‑115 anxiolytic doses were higher with oral treatment than with intraperitoneal treatment.
Peptide
GB-115
Outcome
MixedAnxiolytic dose range by route
Study
n: not reported in source
Animals with different emotional stress responses
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Measurements
Anxiolytic dose
0.006 to 0.1 mg/kg
intraperitoneal
Anxiolytic dose
0.1 to 5 mg/kg
oral
Source sentences
Summary
These data confirmed the dependence of GB-115 effect on the phenotype of emotional stress response and demonstrated a shift of anxiolytic doses of the preparation from 0.006-0.100 mg/kg in intraperitoneal administration to 0.1-5.0 mg/kg in oral treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The anxiolytic effects of GB-115, a retroanalogue of cholecystokinin-4, administered orally to outbred and inbred animals with different level of emotionality, were studied in the open field test and elevated plus-maze test.
Report a problemFND-2413098905

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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