In healthy men given intranasal oxytocin, carriers of the heterozygous CT variant of OXTR rs401015 showed higher right amygdala activity for direct versus averted gaze than the TT group.
In plain wordsIn healthy men given oxytocin, men with the CT gene variant showed more amygdala activity during direct gaze than men with the TT variant.
- Peptide
- Oxytocin
- Outcome
- Not applicableRight amygdala activity, direct > averted gaze, by OXTR rs401015 genotype
- Study
n = 55
- Comparator
- TT genotype
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated · intranasalAs given in this study (human).
Source sentences
The main result revealed that a genetic variation of the OXTR gene (rs401015) modulated the right amygdala activity for the fMRI contrast "direct > averted gaze" under the influence of the neuropeptide oxytocin. Here, carriers of the heterozygous CT variant showed higher activity compared to the TT group.
1 context sentence(design, population, supporting numbers)
N = 55 healthy males were invited to an oxytocin challenge study administered while watching direct vs. averted gaze pictures in an fMRI setting.