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Study · Randomized controlled trial · 2014

3 results

Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome.

Domes G, Kumbier E, Heinrichs M, Herpertz SC

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology26 Sept 2013Cited by 110 (Europe PMC)

PMID24067301 (opens in a new tab)PMCIDPMC3895247 (opens in a new tab)DOI10.1038/npp.2013.254 (opens in a new tab)PepBankPUB-24067301
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with Asperger syndrome, intranasal oxytocin improved performance in a facial emotion recognition task.

    In plain wordsIn adults with Asperger syndrome, nasal oxytocin improved the ability to recognise emotions in faces.

    Peptide
    Oxytocin
    Outcome
    IncreaseFacial emotion recognition performance
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal administration of the neuropeptide oxytocin improved performance in a facial emotion recognition task in individuals with AS.
    1 context sentence
    Summary · context
    Here, we report a randomized double-blind, placebo-controlled trial that examined the neural and behavioral effects of a single dose of intranasal oxytocin on emotion recognition in individuals with Asperger syndrome (AS), a clinical condition characterized by impaired eye gaze and facial emotion recognition.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with Asperger syndrome, intranasal oxytocin was linked to increased left amygdala reactivity in response to facial stimuli.

    In plain wordsIn adults with Asperger syndrome, oxytocin was linked to stronger left amygdala brain responses to faces.

    Peptide
    Oxytocin
    Outcome
    IncreaseLeft amygdala reactivity to facial stimuli
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    This was linked to increased left amygdala reactivity in response to facial stimuli and increased activity in the neural network involved in social cognition.
    1 context sentence
    Summary · context
    Here, we report a randomized double-blind, placebo-controlled trial that examined the neural and behavioral effects of a single dose of intranasal oxytocin on emotion recognition in individuals with Asperger syndrome (AS), a clinical condition characterized by impaired eye gaze and facial emotion recognition.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adults with Asperger syndrome, intranasal oxytocin was linked to increased activity in the neural network involved in social cognition.

    In plain wordsIn adults with Asperger syndrome, oxytocin was linked to more activity in brain areas used for social thinking.

    Peptide
    Oxytocin
    Outcome
    IncreaseActivity in the social cognition neural network
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    increased activity in the neural network involved in social cognition.
    1 context sentence
    Summary · context
    Here, we report a randomized double-blind, placebo-controlled trial that examined the neural and behavioral effects of a single dose of intranasal oxytocin on emotion recognition in individuals with Asperger syndrome (AS), a clinical condition characterized by impaired eye gaze and facial emotion recognition.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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