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Study · Measured the body's own peptide · 2013

2 results

The effect of anabolic steroid administration on passive stretching-induced expression of mechano-growth factor in skeletal muscle.

Ikeda S, Kamikawa Y, Ohwatashi A, Harada K, Yoshida A

TheScientificWorldJournal25 Aug 2013Cited by 5 (Europe PMC)

PMID24062630 (opens in a new tab)PMCIDPMC3767052 (opens in a new tab)DOI10.1155/2013/313605 (opens in a new tab)PepBankPUB-24062630
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Summary

BackgroundStretching of skeletal muscle induces expression of the genes which encode myogenic transcription factors or muscle contractile proteins and results in muscle growth. Anabolic steroids are reported to strengthen muscles. We have previously studied the effects of muscle stretching on gene expression. Here, we studied the effect of a combination of passive stretching and the administration of an anabolic steroid on mRNA expression of a muscle growth factor, insulin-like growth factor-I autocrine variant, or mechano-growth factor (MGF).MethodsTwelve 8-week-old male Wistar rats were used. Metenolone was administered and passive repetitive dorsiflexion and plantar flexion of the ankle joint performed under deep anesthesia. After 24 h, the gastrocnemius muscles were removed and the mRNA expression of insulin-like growth factor-I autocrine variant was measured using quantitative real-time polymerase chain reaction.ResultsRepetitive stretching in combination with metenolone, but not stretching alone, significantly increased MGF mRNA expression.ConclusionAnabolic steroids enhance the effect of passive stretching on MGF expression in skeletal muscle.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In Wistar rats, passive stretching combined with metenolone significantly increased MGF mRNA expression in gastrocnemius muscle.

    In plain wordsIn rats, stretching combined with a steroid raised the body's own MGF gene activity in muscle.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF mRNA expression, stretching plus metenolone
    Study

    ratn = 12

    Wistar rats, gastrocnemius muscle
    Outcome group
    Exercise and physical function · Musculoskeletal

    Source sentences

    Summary
    Repetitive stretching in combination with metenolone, but not stretching alone, significantly increased MGF mRNA expression.
    2 context sentences
    Summary · context
    Twelve 8-week-old male Wistar rats were used.
    Summary · context
    Metenolone was administered and passive repetitive dorsiflexion and plantar flexion of the ankle joint performed under deep anesthesia.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In Wistar rats, passive stretching alone did not significantly increase MGF mRNA expression in gastrocnemius muscle.

    In plain wordsIn rats, stretching alone did not raise the body's own MGF gene activity in muscle.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF mRNA expression, stretching alone
    Study

    ratn = 12

    Wistar rats, gastrocnemius muscle
    Outcome group
    Exercise and physical function · Musculoskeletal

    Source sentences

    Summary
    Repetitive stretching in combination with metenolone, but not stretching alone, significantly increased MGF mRNA expression.
    2 context sentences
    Summary · context
    Twelve 8-week-old male Wistar rats were used.
    Summary · context
    Metenolone was administered and passive repetitive dorsiflexion and plantar flexion of the ankle joint performed under deep anesthesia.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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