Functional and transcriptomic analysis of the regulation of osteoblasts by mechano-growth factor E peptide.

Xin J, Wang Y, Wang Z, Lin F

Biotechnology and applied biochemistry20 Dec 2013Cited by 8 (Europe PMC)

PMID24033831DOI10.1002/bab.1152PepBankPUB-24033831

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In rat calvarial osteoblasts, MGF-Ct24E significantly increased proliferation during the first 3 days.
In plain wordsIn rat cells, the MGF-Ct24E peptide made bone-forming cells multiply more in the first 3 days.
Peptide
MGF / PEG-MGF
Outcome
IncreaseOsteoblast proliferation in the first 3 days
Study
ratn: not reported in source
rat calvarial osteoblasts
Outcome group
Cell proliferation and differentiation · Musculoskeletal
Studied dose
Dose not stated · first 3 daysAs given in this study (rat).
Source sentences
Summary
MGF-Ct24E significantly increased the proliferation and retarded the differentiation of osteoblasts during the first 3 days
1 context sentence(design, population, supporting numbers)
Summary · context
Accordingly, the aim of this study was to investigate the role of MGF-Ct24E in the proliferation, differentiation, and mineralization of rat calvarial osteoblasts.
Report a problemFND-2403383101
02LabIn vitro (cells)Efficacy outcome
In rat calvarial osteoblasts, MGF-Ct24E retarded differentiation during the first 3 days.
In plain wordsIn rat cells, the MGF-Ct24E peptide slowed the maturing of bone-forming cells in the first 3 days.
Peptide
MGF / PEG-MGF
Outcome
DecreaseOsteoblast differentiation in the first 3 days
Study
ratn: not reported in source
rat calvarial osteoblasts
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · first 3 daysAs given in this study (rat).
Source sentences
Summary
MGF-Ct24E significantly increased the proliferation and retarded the differentiation of osteoblasts during the first 3 days
1 context sentence(design, population, supporting numbers)
Summary · context
Accordingly, the aim of this study was to investigate the role of MGF-Ct24E in the proliferation, differentiation, and mineralization of rat calvarial osteoblasts.
Report a problemFND-2403383102
03LabIn vitro (cells)Efficacy outcome
In rat calvarial osteoblasts, prolonged treatment with MGF-Ct24E for up to 3 weeks promoted cell differentiation.
In plain wordsIn rat cells, longer treatment with the MGF-Ct24E peptide helped bone-forming cells mature.
Peptide
MGF / PEG-MGF
Outcome
IncreaseOsteoblast differentiation after prolonged treatment
Study
ratn: not reported in source
rat calvarial osteoblasts
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · up to 3 weeksAs given in this study (rat).
Source sentences
Summary
prolonged treatment with MGF-Ct24E for up to 3 weeks promoted cell differentiation
1 context sentence(design, population, supporting numbers)
Summary · context
Accordingly, the aim of this study was to investigate the role of MGF-Ct24E in the proliferation, differentiation, and mineralization of rat calvarial osteoblasts.
Report a problemFND-2403383103
04LabIn vitro (cells)Mechanism
In rat calvarial osteoblasts, MGF-Ct24E enhanced the expression of genes associated with osteoblast proliferation and the cell cycle.
In plain wordsIn rat cells, the MGF-Ct24E peptide raised the activity of genes linked to cell growth.
Peptide
MGF / PEG-MGF
Outcome
IncreaseExpression of genes for osteoblast proliferation and the cell cycle
Study
ratn: not reported in source
rat calvarial osteoblasts
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
MGF-Ct24E enhanced the expression of genes associated with osteoblast proliferation and the cell cycle
1 context sentence(design, population, supporting numbers)
Summary · context
To determine the molecular mechanisms behind this plurality, we carried out global transcriptional profiling of osteoblasts in response to MGF-Ct24E and identified differentially expressed genes by bioinformatics analysis.
Report a problemFND-2403383104
05LabIn vitro (cells)Mechanism
In rat calvarial osteoblasts, MGF-Ct24E downregulated genes involved with osteoblast differentiation, skeletal system, and bone development.
In plain wordsIn rat cells, the MGF-Ct24E peptide lowered the activity of genes linked to bone cell maturing and bone development.
Peptide
MGF / PEG-MGF
Outcome
DecreaseExpression of genes for osteoblast differentiation, skeletal system and bone development
Study
ratn: not reported in source
rat calvarial osteoblasts
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
downregulated genes involved with osteoblast differentiation, skeletal system, and bone development.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine the molecular mechanisms behind this plurality, we carried out global transcriptional profiling of osteoblasts in response to MGF-Ct24E and identified differentially expressed genes by bioinformatics analysis.
Report a problemFND-2403383105
06LabIn vitro (cells)Mechanism
In rat calvarial osteoblasts, MGF-Ct24E directly altered focal adhesion and cell cycle progression, in addition to regulating the actin cytoskeleton and gap junctions.
In plain wordsIn rat cells, the MGF-Ct24E peptide changed cell attachment, the cell cycle, the cell skeleton and cell links.
Peptide
MGF / PEG-MGF
Outcome
Direction not reportedFocal adhesion, cell cycle progression, actin cytoskeleton and gap junction pathways
Study
ratn: not reported in source
rat calvarial osteoblasts
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Moreover, KEGG pathway-based analysis indicated that MGF-Ct24E directly altered focal adhesion and cell cycle progression, in addition to regulating the actin cytoskeleton and gap junctions.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine the molecular mechanisms behind this plurality, we carried out global transcriptional profiling of osteoblasts in response to MGF-Ct24E and identified differentially expressed genes by bioinformatics analysis.
Report a problemFND-2403383106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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