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Study · Randomized controlled trial · 2013

4 results

Oxytocin effects on neural correlates of self-referential processing.

Liu Y, Sheng F, Woodcock KA, Han S

Biological psychology18 Aug 2013Cited by 35 (Europe PMC)

PMID23965321 (opens in a new tab)DOI10.1016/j.biopsycho.2013.08.003 (opens in a new tab)PepBankPUB-23965321
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In adults, intranasal oxytocin versus placebo reduced the differential amplitude of the fronto-central P2 positivity during self- versus valence-judgments.

    In plain wordsIn adults, oxytocin reduced a brain-signal difference between judging oneself and judging word meaning, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseP2 differential amplitude, self- vs valence-judgments
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    We found that OT vs. placebo treatment reduced the differential amplitudes of a fronto-central positivity at 220-280 ms (P2) during self- vs. valence-judgments.
    1 context sentence
    Summary · context
    Using a double-blind, placebo-controlled within-subject design, we recorded event-related potentials (ERPs) from adults during trait judgments about oneself and a celebrity and during judgments on word valence, after intranasal OT or placebo administration.
  2. 02HumanRandomized controlled trialMechanism

    In adults, oxytocin versus placebo tended to reduce the differential late positive potential amplitude during self-judgments.

    In plain wordsIn adults, oxytocin tended to lower a late brain signal during self-judgments, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseLPP differential amplitude during self-judgments
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OT vs. placebo treatment tended to reduce the differential amplitude of a late positive potential at 520-1000 ms (LPP) during self-judgments
    1 context sentence
    Summary · context
    Using a double-blind, placebo-controlled within-subject design, we recorded event-related potentials (ERPs) from adults during trait judgments about oneself and a celebrity and during judgments on word valence, after intranasal OT or placebo administration.
  3. 03HumanRandomized controlled trialMechanism

    In adults, oxytocin versus placebo tended to increase the differential late positive potential amplitude during other-judgments.

    In plain wordsIn adults, oxytocin tended to raise a late brain signal while judging a celebrity, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseLPP differential amplitude during other-judgments
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OT vs. placebo treatment tended to reduce the differential amplitude of a late positive potential at 520-1000 ms (LPP) during self-judgments but to increase the differential LPP amplitude during other-judgments.
    1 context sentence
    Summary · context
    Using a double-blind, placebo-controlled within-subject design, we recorded event-related potentials (ERPs) from adults during trait judgments about oneself and a celebrity and during judgments on word valence, after intranasal OT or placebo administration.
  4. 04HumanRandomized controlled trialMechanism

    In adults, oxytocin effects on the differential P2 and LPP amplitudes to self- versus celebrity-judgments correlated positively with interdependence of self-construals.

    In plain wordsIn adults, the brain-signal changes under oxytocin were larger in people who saw themselves as more interdependent with others.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of OT effects on P2 and LPP with self-construal interdependence
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OT effects on the differential P2 and LPP amplitudes to self- vs. celebrity-judgments were positively correlated with a measure of interdependence of self-construals.
    1 context sentence
    Summary · context
    Using a double-blind, placebo-controlled within-subject design, we recorded event-related potentials (ERPs) from adults during trait judgments about oneself and a celebrity and during judgments on word valence, after intranasal OT or placebo administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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