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Study · Randomized controlled trial · n = 13 · 2013

2 results

Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder.

Brüne M, Ebert A, Kolb M, Tas C, Edel MA, Roser P

Human psychopharmacology1 Nov 2013Cited by 39 (Europe PMC)

PMID23950057 (opens in a new tab)DOI10.1002/hup.2343 (opens in a new tab)PepBankPUB-23950057
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with borderline personality disorder, intranasal oxytocin abolished the avoidant reaction to angry faces seen under placebo.

    In plain wordsIn adults with borderline personality disorder, oxytocin removed the avoidant reaction to angry faces that was seen with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseAvoidant reaction to angry faces (dot probe task)
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This behavioral response (as well as the correlation) was abolished in the oxytocin condition.
    2 context sentences
    Summary · context
    In the placebo condition, patients with BPD (but not controls) showed an avoidant reaction to angry faces (but not happy faces).
    Summary · context
    In a double-blind randomized placebo-controlled study, 13 BPD patients and 13 controls performed a dot probe task to examine attentional biases to happy and angry faces after intranasal application of oxytocin or placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with borderline personality disorder, intranasal oxytocin abolished the correlation between the avoidant reaction and the severity of childhood trauma seen under placebo.

    In plain wordsIn adults with borderline personality disorder, oxytocin removed the link between avoidance of angry faces and childhood trauma that was seen with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseCorrelation of avoidant reaction with childhood trauma severity
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This behavioral response (as well as the correlation) was abolished in the oxytocin condition.
    2 context sentences
    Summary · context
    The strength of the avoidant reaction correlated with the severity of childhood trauma.
    Summary · context
    In a double-blind randomized placebo-controlled study, 13 BPD patients and 13 controls performed a dot probe task to examine attentional biases to happy and angry faces after intranasal application of oxytocin or placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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