Skip to content

Study · Animal study (in vivo) · rat · 2013

8 results

Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat.

Hansen HH, Jensen MM, Overgaard A, Weikop P, Mikkelsen JD

Pharmacology, biochemistry, and behavior7 Aug 2013Cited by 23 (Europe PMC)

PMID23932919 (opens in a new tab)DOI10.1016/j.pbb.2013.07.018 (opens in a new tab)PepBankPUB-23932919
Publisher pagePubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, tesofensine produced a pronounced appetite-suppressing response compared with age-matched chow-fed rats.

    In plain wordsIn obese rats, tesofensine produced a pronounced appetite-suppressing response compared with age-matched chow-fed rats.

    Peptide
    Tesofensine
    Outcome
    DecreaseAppetite suppression
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Comparator
    Age-matched chow-fed rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    2.0 mg/kg/day · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    Tesofensine treatment (2.0 mg/kg/day for 14 days) caused a pronounced anorexigenic and weight-reducing response in DIO rats as compared to age-matched chow-fed rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In obese rats, tesofensine produced a pronounced weight-reducing response compared with age-matched chow-fed rats.

    In plain wordsIn obese rats, tesofensine produced a pronounced weight-reducing response compared with age-matched chow-fed rats.

    Peptide
    Tesofensine
    Outcome
    DecreaseBody weight
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Comparator
    Age-matched chow-fed rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    2.0 mg/kg/day · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    Tesofensine treatment (2.0 mg/kg/day for 14 days) caused a pronounced anorexigenic and weight-reducing response in DIO rats as compared to age-matched chow-fed rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In obese rats, acute tesofensine normalized accumbal dopamine levels.

    In plain wordsIn obese rats, acute tesofensine normalized accumbal dopamine levels.

    Peptide
    Tesofensine
    Outcome
    IncreaseAccumbal dopamine normalization
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 mg/kg · Acute administrationAs given in this study (rat).

    Source sentences

    Summary
    While acute administration of tesofensine (2.0 mg/kg) normalized accumbal dopamine levels in DIO rats, the drug had no effect on dopamine levels in chow-fed rats.
    1 context sentence
    Summary · context
    DIO rats also exhibited a marked reduction in baseline extracellular dopamine levels in the nucleus accumbens (NAcc) and prefrontal cortex (PFC), as compared to chow-fed rats using microdialysis.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In chow-fed rats, acute tesofensine did not affect dopamine levels.

    In plain wordsIn chow-fed rats, acute tesofensine did not affect dopamine levels.

    Peptide
    Tesofensine
    Outcome
    No significant changeDopamine in chow-fed rats
    Study

    ratn: not reported in source

    Chow-fed rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.0 mg/kg · Acute administrationAs given in this study (rat).

    Source sentences

    Summary
    While acute administration of tesofensine (2.0 mg/kg) normalized accumbal dopamine levels in DIO rats, the drug had no effect on dopamine levels in chow-fed rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In obese rats, tesofensine evoked a stronger nucleus accumbens dopamine response than in chow-fed rats.

    In plain wordsIn obese rats, tesofensine evoked a stronger nucleus accumbens dopamine response than in chow-fed rats.

    Peptide
    Tesofensine
    Outcome
    IncreaseNucleus accumbens dopamine response
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Comparator
    Chow-fed rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tesofensine evoked a stronger stimulatory response on NAcc and PFC dopamine levels in DIO rats, and also induced discrete changes in striatal dopamine D2 receptor expression and transporter binding.
    1 context sentence
    Summary · context
    While acute administration of tesofensine (2.0 mg/kg) normalized accumbal dopamine levels in DIO rats, the drug had no effect on dopamine levels in chow-fed rats.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In obese rats, tesofensine evoked a stronger prefrontal cortex dopamine response than in chow-fed rats.

    In plain wordsIn obese rats, tesofensine evoked a stronger prefrontal cortex dopamine response than in chow-fed rats.

    Peptide
    Tesofensine
    Outcome
    IncreasePrefrontal cortex dopamine response
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Comparator
    Chow-fed rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tesofensine evoked a stronger stimulatory response on NAcc and PFC dopamine levels in DIO rats, and also induced discrete changes in striatal dopamine D2 receptor expression and transporter binding.
    1 context sentence
    Summary · context
    While acute administration of tesofensine (2.0 mg/kg) normalized accumbal dopamine levels in DIO rats, the drug had no effect on dopamine levels in chow-fed rats.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In obese rats, tesofensine induced discrete changes in striatal dopamine D2 receptor expression.

    In plain wordsIn obese rats, tesofensine changed striatal dopamine D2 receptor expression, with direction unspecified.

    Peptide
    Tesofensine
    Outcome
    Direction not reportedStriatal dopamine D2 receptor expression
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tesofensine evoked a stronger stimulatory response on NAcc and PFC dopamine levels in DIO rats, and also induced discrete changes in striatal dopamine D2 receptor expression and transporter binding.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In obese rats, tesofensine induced discrete changes in striatal transporter binding.

    In plain wordsIn obese rats, tesofensine changed striatal transporter binding, with direction unspecified.

    Peptide
    Tesofensine
    Outcome
    Direction not reportedStriatal transporter binding
    Study

    ratn: not reported in source

    Diet-induced obese rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tesofensine evoked a stronger stimulatory response on NAcc and PFC dopamine levels in DIO rats, and also induced discrete changes in striatal dopamine D2 receptor expression and transporter binding.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.