A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans.

Bakermans-Kranenburg MJ, van Ijzendoorn MH

Psychiatric genetics1 Apr 2014Cited by 158 (Europe PMC)

PMID23921259DOI10.1097/ypg.0b013e3283643684PepBankPUB-23921259

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01HumanNot a test of Oxytocin aloneSystematic reviewOther
In the biology domain, combined effect sizes for OXTR rs53576 and rs2254298 did not differ from zero.
In plain wordsTwo oxytocin receptor gene variants were not linked to biological outcomes in pooled studies.
Peptide
Oxytocin
Outcome
No significant changeOXTR SNPs and biology domain
Study
n: not reported in source
Outcome group
Genetic association · Nervous system and cognition
Source sentences
Summary
Combined effect sizes did not differ from zero in any of the domains, nor for all domains combined.
1 context sentence(design, population, supporting numbers)
Summary · context
We carried out meta-analyses for these two SNPs, covering five domains of outcomes: (a) biology, (b) personality, (c) social behavior, (d) psychopathology, and (e) autism, on the basis of 82 pertinent effect sizes, 48 for OXTR rs53576 (N=17 559) and 34 for OXTR rs2254298 (N=13 547).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2392125901
02HumanNot a test of Oxytocin aloneSystematic reviewOther
In the personality domain, combined effect sizes for OXTR rs53576 and rs2254298 did not differ from zero.
In plain wordsTwo oxytocin receptor gene variants were not linked to personality in pooled studies.
Peptide
Oxytocin
Outcome
No significant changeOXTR SNPs and personality domain
Study
n: not reported in source
Outcome group
Genetic association · Nervous system and cognition
Source sentences
Summary
Combined effect sizes did not differ from zero in any of the domains, nor for all domains combined.
1 context sentence(design, population, supporting numbers)
Summary · context
We carried out meta-analyses for these two SNPs, covering five domains of outcomes: (a) biology, (b) personality, (c) social behavior, (d) psychopathology, and (e) autism, on the basis of 82 pertinent effect sizes, 48 for OXTR rs53576 (N=17 559) and 34 for OXTR rs2254298 (N=13 547).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2392125902
03HumanNot a test of Oxytocin aloneSystematic reviewOther
In the social behavior domain, combined effect sizes for OXTR rs53576 and rs2254298 did not differ from zero.
In plain wordsTwo oxytocin receptor gene variants were not linked to social behavior in pooled studies.
Peptide
Oxytocin
Outcome
No significant changeOXTR SNPs and social behavior domain
Study
n: not reported in source
Outcome group
Genetic association · Nervous system and cognition
Source sentences
Summary
Combined effect sizes did not differ from zero in any of the domains, nor for all domains combined.
1 context sentence(design, population, supporting numbers)
Summary · context
We carried out meta-analyses for these two SNPs, covering five domains of outcomes: (a) biology, (b) personality, (c) social behavior, (d) psychopathology, and (e) autism, on the basis of 82 pertinent effect sizes, 48 for OXTR rs53576 (N=17 559) and 34 for OXTR rs2254298 (N=13 547).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2392125903
04HumanNot a test of Oxytocin aloneSystematic reviewOther
In the psychopathology domain, combined effect sizes for OXTR rs53576 and rs2254298 did not differ from zero.
In plain wordsTwo oxytocin receptor gene variants were not linked to psychopathology in pooled studies.
Peptide
Oxytocin
Outcome
No significant changeOXTR SNPs and psychopathology domain
Study
n: not reported in source
Outcome group
Genetic association · Nervous system and cognition
Source sentences
Summary
Combined effect sizes did not differ from zero in any of the domains, nor for all domains combined.
1 context sentence(design, population, supporting numbers)
Summary · context
We carried out meta-analyses for these two SNPs, covering five domains of outcomes: (a) biology, (b) personality, (c) social behavior, (d) psychopathology, and (e) autism, on the basis of 82 pertinent effect sizes, 48 for OXTR rs53576 (N=17 559) and 34 for OXTR rs2254298 (N=13 547).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2392125904
05HumanNot a test of Oxytocin aloneSystematic reviewOther
In the autism domain, combined effect sizes for OXTR rs53576 and rs2254298 did not differ from zero.
In plain wordsTwo oxytocin receptor gene variants were not linked to autism in pooled studies.
Peptide
Oxytocin
Outcome
No significant changeOXTR SNPs and autism domain
Study
n: not reported in source
Outcome group
Genetic association · Nervous system and cognition
Source sentences
Summary
Combined effect sizes did not differ from zero in any of the domains, nor for all domains combined.
1 context sentence(design, population, supporting numbers)
Summary · context
We carried out meta-analyses for these two SNPs, covering five domains of outcomes: (a) biology, (b) personality, (c) social behavior, (d) psychopathology, and (e) autism, on the basis of 82 pertinent effect sizes, 48 for OXTR rs53576 (N=17 559) and 34 for OXTR rs2254298 (N=13 547).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2392125905
06HumanNot a test of Oxytocin aloneSystematic reviewOther
Across all domains combined, effect sizes for OXTR rs53576 and rs2254298 did not differ from zero.
In plain wordsTwo oxytocin receptor gene variants were not linked to the studied outcomes when all domains were combined.
Peptide
Oxytocin
Outcome
No significant changeOXTR SNPs, all domains combined
Study
n: not reported in source
Outcome group
Genetic association · Nervous system and cognition
Source sentences
Summary
Combined effect sizes did not differ from zero in any of the domains, nor for all domains combined.
1 context sentence(design, population, supporting numbers)
Summary · context
We carried out meta-analyses for these two SNPs, covering five domains of outcomes: (a) biology, (b) personality, (c) social behavior, (d) psychopathology, and (e) autism, on the basis of 82 pertinent effect sizes, 48 for OXTR rs53576 (N=17 559) and 34 for OXTR rs2254298 (N=13 547).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2392125906
07HumanNot a test of Oxytocin aloneSystematic reviewOther
Clinical status, age and sex did not moderate the OXTR effect sizes.
In plain wordsClinical status, age and sex did not change the size of the gene effects.
Peptide
Oxytocin
Outcome
No significant changeModeration by clinical status, age and sex
Study
n: not reported in source
Outcome group
Genetic association · Nervous system and cognition
Source sentences
Summary
Clinical status, age, and sex did not moderate the effect sizes.
1 context sentence(design, population, supporting numbers)
Summary · context
We carried out meta-analyses for these two SNPs, covering five domains of outcomes: (a) biology, (b) personality, (c) social behavior, (d) psychopathology, and (e) autism, on the basis of 82 pertinent effect sizes, 48 for OXTR rs53576 (N=17 559) and 34 for OXTR rs2254298 (N=13 547).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2392125907
08HumanNot a test of Oxytocin aloneSystematic reviewOther
Minor allele frequency was related to ethnicity, with significantly lower minor allele frequencies in samples with predominantly Caucasian participants.
In plain wordsMinor allele frequencies were lower in samples with mostly Caucasian participants.
Peptide
Oxytocin
Outcome
DecreaseMinor allele frequency by ethnicity
Study
n: not reported in source
Comparator
Samples without predominantly Caucasian participants
Outcome group
Genetic association · Nervous system and cognition
Source sentences
Summary
Minor allele frequency was related to ethnicity, with significantly lower minor allele frequencies in samples with predominantly Caucasian participants.
1 context sentence(design, population, supporting numbers)
Summary · context
We carried out meta-analyses for these two SNPs, covering five domains of outcomes: (a) biology, (b) personality, (c) social behavior, (d) psychopathology, and (e) autism, on the basis of 82 pertinent effect sizes, 48 for OXTR rs53576 (N=17 559) and 34 for OXTR rs2254298 (N=13 547).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2392125908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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