Skip to content

Study · Randomized controlled trial · n = 35 · 2013

5 results

Oxytocin administration alters HPA reactivity in the context of parent-infant interaction.

Weisman O, Zagoory-Sharon O, Feldman R

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology29 Jul 2013Cited by 51 (Europe PMC)

PMID23906646 (opens in a new tab)DOI10.1016/j.euroneuro.2013.06.006 (opens in a new tab)PepBankPUB-23906646
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In fathers, intranasal oxytocin increased the overall cortisol response to a parent-infant stress paradigm versus placebo.

    In plain wordsIn fathers, oxytocin raised the cortisol stress response during interaction with their infant compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseFather cortisol response to stress paradigm
    Study

    n = 35

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Results showed that OT increased fathers' overall CT response to the stress paradigm.
    1 context sentence
    Summary · context
    Utilizing a double-blind, placebo-controlled, within-subject design, 35 fathers and their 5-month-old infants were observed in a face-to-face-still-face paradigm twice, one week apart.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In infants with high parent-infant synchrony, oxytocin given to the father elevated infant HPA reactivity.

    In plain wordsIn infants who interacted closely with their father, the father's oxytocin raised the infant's stress hormone response.

    Peptide
    Oxytocin
    Outcome
    IncreaseInfant HPA reactivity, high parent-infant synchrony
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Among infants experiencing high parent-infant synchrony, OT elevated infant HPA reactivity
    1 context sentence
    Summary · context
    Utilizing a double-blind, placebo-controlled, within-subject design, 35 fathers and their 5-month-old infants were observed in a face-to-face-still-face paradigm twice, one week apart.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In infants with high parent-infant synchrony, oxytocin given to the father increased infant social gaze to the father during the still-face.

    In plain wordsIn infants who interacted closely with their father, the father's oxytocin increased the infant's gaze at the father.

    Peptide
    Oxytocin
    Outcome
    IncreaseInfant social gaze to father, high parent-infant synchrony
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Among infants experiencing high parent-infant synchrony, OT elevated infant HPA reactivity and increased infant social gaze to the father while father maintained a still-face.
    1 context sentence
    Summary · context
    Utilizing a double-blind, placebo-controlled, within-subject design, 35 fathers and their 5-month-old infants were observed in a face-to-face-still-face paradigm twice, one week apart.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In infants with low parent-infant synchrony, oxytocin given to the father reduced the infant's stress response.

    In plain wordsIn infants who interacted less closely with their father, the father's oxytocin lowered the infant's stress response.

    Peptide
    Oxytocin
    Outcome
    DecreaseInfant stress response, low parent-infant synchrony
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    among infants experiencing low social synchrony, parental OT reduced the infant's stress response
    1 context sentence
    Summary · context
    Utilizing a double-blind, placebo-controlled, within-subject design, 35 fathers and their 5-month-old infants were observed in a face-to-face-still-face paradigm twice, one week apart.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In infants with low social synchrony, oxytocin given to the father diminished infant social gaze toward the unavailable father.

    In plain wordsIn infants who interacted less closely with their father, the father's oxytocin reduced the infant's gaze at the father.

    Peptide
    Oxytocin
    Outcome
    DecreaseInfant social gaze to father, low parent-infant synchrony
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    among infants experiencing low social synchrony, parental OT reduced the infant's stress response and diminished social gaze toward the unavailable father.
    1 context sentence
    Summary · context
    Utilizing a double-blind, placebo-controlled, within-subject design, 35 fathers and their 5-month-old infants were observed in a face-to-face-still-face paradigm twice, one week apart.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.