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Study · Randomized controlled trial · n = 38 · 2014

3 results

Nasal oxytocin for social deficits in childhood autism: a randomized controlled trial.

Dadds MR, MacDonald E, Cauchi A, Williams K, Levy F, Brennan J

Journal of autism and developmental disorders1 Mar 2014Cited by 192 (Europe PMC)

PMID23888359 (opens in a new tab)DOI10.1007/s10803-013-1899-3 (opens in a new tab)PepBankPUB-23888359
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male youths with autism spectrum disorders, intranasal oxytocin did not significantly improve emotion recognition versus placebo.

    In plain wordsIn boys and young men with autism, nasal oxytocin did not clearly improve emotion recognition compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeEmotion recognition
    Study

    n = 38

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    24 or 12 IU depending on weight · intranasal · four consecutive daysAs given in this study (human).

    Source sentences

    Summary
    Compared to placebo, intranasal oxytocin did not significantly improve emotion recognition
    1 context sentence
    Summary · context
    38 male youths (7-16 years old) with autism spectrum disorders were administered 24 or 12 international units (depending on weight) intranasal placebo or oxytocin once daily over four consecutive days.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male youths with autism spectrum disorders, intranasal oxytocin did not significantly improve social interaction skills versus placebo.

    In plain wordsIn boys and young men with autism, nasal oxytocin did not clearly improve social interaction skills compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSocial interaction skills
    Study

    n = 38

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 or 12 IU depending on weight · intranasal · four consecutive daysAs given in this study (human).

    Source sentences

    Summary
    Compared to placebo, intranasal oxytocin did not significantly improve emotion recognition, social interaction skills, or general behavioral adjustment in male youths with autism spectrum disorders.
    1 context sentence
    Summary · context
    38 male youths (7-16 years old) with autism spectrum disorders were administered 24 or 12 international units (depending on weight) intranasal placebo or oxytocin once daily over four consecutive days.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In male youths with autism spectrum disorders, intranasal oxytocin did not significantly improve general behavioral adjustment versus placebo.

    In plain wordsIn boys and young men with autism, nasal oxytocin did not clearly improve general behavior compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeGeneral behavioral adjustment
    Study

    n = 38

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 or 12 IU depending on weight · intranasal · four consecutive daysAs given in this study (human).

    Source sentences

    Summary
    Compared to placebo, intranasal oxytocin did not significantly improve emotion recognition, social interaction skills, or general behavioral adjustment in male youths with autism spectrum disorders.
    1 context sentence
    Summary · context
    38 male youths (7-16 years old) with autism spectrum disorders were administered 24 or 12 international units (depending on weight) intranasal placebo or oxytocin once daily over four consecutive days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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