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Study · Systematic review · 2014

3 results

Oxytocin and pain: a systematic review and synthesis of findings.

Rash JA, Aguirre-Camacho A, Campbell TS

The Clinical journal of pain1 May 2014Cited by 131 (Europe PMC)

PMID23887343 (opens in a new tab)DOI10.1097/ajp.0b013e31829f57df (opens in a new tab)PepBankPUB-23887343
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 1 result from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In a systematic review, preliminary human research suggested that oxytocin decreases pain sensitivity, but reliability and stability cannot yet be determined.

    In plain wordsEarly human studies suggest oxytocin lowers pain sensitivity, but how reliable this is cannot yet be said.

    Peptide
    Oxytocin
    Outcome
    DecreasePain sensitivity in humans
    Study

    n: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preliminary research with humans offers consistent evidence to suggest that OT decreases pain sensitivity, though the reliability and stability of such effects cannot yet be determined.
    1 context sentence
    Summary · context
    Of a total of 1166 articles returned, 50 (9 human, 33 animal, and 8 spinal cord samples) met full inclusion criteria and were included in the review.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a systematic review of animal studies, oxytocin increased pain tolerance in 29 of 33 animal studies.

    In plain wordsIn animals, oxytocin raised pain tolerance in most of the studies reviewed.

    Peptide
    Oxytocin
    Outcome
    IncreasePain tolerance in animal studies
    Study

    n: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT had a reliable effect as defined by increasing pain tolerance in 29 of 33 animal studies reviewed.
    1 context sentence
    Summary · context
    Of a total of 1166 articles returned, 50 (9 human, 33 animal, and 8 spinal cord samples) met full inclusion criteria and were included in the review.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In animal studies, the increase in pain tolerance with oxytocin persisted across central and peripheral administration and across types of noxious stimulus.

    In plain wordsIn animals, the pain-tolerance effect of oxytocin held across ways of giving it and across types of painful stimulus.

    Peptide
    Oxytocin
    Outcome
    IncreasePain tolerance across administration routes and stimuli in animals
    Study

    n: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · central and peripheralAs given in this study.

    Source sentences

    Summary
    This effect persisted across central and peripheral modes of administration and type of noxious stimulus used (eg, heat, electric).
    1 context sentence
    Summary · context
    Of a total of 1166 articles returned, 50 (9 human, 33 animal, and 8 spinal cord samples) met full inclusion criteria and were included in the review.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 4Results postedNCT02550093

The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold

Northwestern Universityn = 20Apr 2015 to Nov 2016

Healthy

Trial pageClinicalTrials.govUpdated 16 May 2022

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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