Cerebrolysin Ameloriates Cognitive Deficits in Type III Diabetic Rats.

Georgy GS, Nassar NN, Mansour HA, Abdallah DM

PloS one19 Jun 2013Cited by 31 (Europe PMC)

PMID23840309PMCIDPMC3686810DOI10.1371/journal.pone.0064847PepBankPUB-23840309

Summary

Cerebrolysin (CBL), a mixture of several active peptide fragments and neurotrophic factors including brain-derived neurotrophic factor (BDNF), is currently used in the management of cognitive alterations in patients with dementia. Since Cognitive decline as well as increased dementia are strongly associated with diabetes and previous studies addressed the protective effect of BDNF in metabolic syndrome and type 2 diabetes; hence this work aimed to evaluate the potential neuroprotective effect of CBL in modulating the complications of hyperglycaemia experimentally induced by streptozotocin (STZ) on the rat brain hippocampus. To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups. Diabetes was confirmed by hyperglycemia and elevated glycated haemoglobin (HbA1c%), which were associated by weight loss, elevated tumor necrosis factor (TNF)-α and decreased insulin growth factor (IGF)-1β in the serum. Uncontrolled hyperglycemia caused learning and memory impairments that corroborated degenerative changes, neuronal loss and expression of caspase (Casp)-3 in the hippocampal area of STZ-diabetic rats. Behavioral deficits were associated by decreased hippocampal glutamate (GLU), glycine, serotonin (5-HT) and dopamine. Moreover, diabetic rats showed an increase in hippocampal nitric oxide and thiobarbituric acid reactive substances versus decreased non-protein sulfhydryls. Though CBL did not affect STZ-induced hyperglycemia, it partly improved body weight as well as HbA1c%. Such effects were associated by enhancement in both learning and memory as well as apparent normal cellularity in CA1and CA3 areas and reduced Casp-3 expression. CBL improved serum TNF-α and IGF-1β, GLU and 5-HT as well as hampering oxidative biomarkers. In conclusion, CBL possesses neuroprotection against diabetes-associated cerebral neurodegeneration and cognitive decline via anti-inflammatory, antioxidant and antiapototic effects.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In STZ-diabetic rats, CBL did not affect hyperglycemia compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL did not change high blood glucose compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
No significant changeHyperglycemia
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Though CBL did not affect STZ-induced hyperglycemia, it partly improved body weight as well as HbA1c%.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030901
02AnimalAnimal study (in vivo)Efficacy outcome
In STZ-diabetic rats, CBL partly improved body weight compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL partly improved body weight compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
IncreaseBody weight
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Though CBL did not affect STZ-induced hyperglycemia, it partly improved body weight as well as HbA1c%.
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetes was confirmed by hyperglycemia and elevated glycated haemoglobin (HbA1c%), which were associated by weight loss, elevated tumor necrosis factor (TNF)-α and decreased insulin growth factor (IGF)-1β in the serum.
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030902
03AnimalAnimal study (in vivo)Efficacy outcome
In STZ-diabetic rats, CBL partly improved elevated HbA1c compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL partly reduced elevated HbA1c compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
DecreaseHbA1c
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Though CBL did not affect STZ-induced hyperglycemia, it partly improved body weight as well as HbA1c%.
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetes was confirmed by hyperglycemia and elevated glycated haemoglobin (HbA1c%), which were associated by weight loss, elevated tumor necrosis factor (TNF)-α and decreased insulin growth factor (IGF)-1β in the serum.
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030903
04AnimalAnimal study (in vivo)Efficacy outcome
In STZ-diabetic rats, CBL enhanced learning compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL improved learning compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
IncreaseLearning
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Such effects were associated by enhancement in both learning and memory as well as apparent normal cellularity in CA1and CA3 areas and reduced Casp-3 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030904
05AnimalAnimal study (in vivo)Efficacy outcome
In STZ-diabetic rats, CBL enhanced memory compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL improved memory compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
IncreaseMemory
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Such effects were associated by enhancement in both learning and memory as well as apparent normal cellularity in CA1and CA3 areas and reduced Casp-3 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030905
06AnimalAnimal study (in vivo)Efficacy outcome
In STZ-diabetic rats, CBL treatment was associated with apparent normal cellularity in CA1 and CA3 areas.
In plain wordsIn rats with diabetes, CBL treatment was linked to apparently normal hippocampal cell populations compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
IncreaseCA1 and CA3 cellularity
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Such effects were associated by enhancement in both learning and memory as well as apparent normal cellularity in CA1and CA3 areas and reduced Casp-3 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030906
07AnimalAnimal study (in vivo)Mechanism
In STZ-diabetic rats, CBL reduced Casp-3 expression compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL reduced Casp-3 expression compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
DecreaseCasp-3 expression
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Such effects were associated by enhancement in both learning and memory as well as apparent normal cellularity in CA1and CA3 areas and reduced Casp-3 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030907
08AnimalAnimal study (in vivo)Efficacy outcome
In STZ-diabetic rats, CBL improved elevated serum TNF-α compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL reduced elevated serum TNF-α compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
DecreaseSerum TNF-alpha
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
CBL improved serum TNF-α and IGF-1β, GLU and 5-HT as well as hampering oxidative biomarkers.
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetes was confirmed by hyperglycemia and elevated glycated haemoglobin (HbA1c%), which were associated by weight loss, elevated tumor necrosis factor (TNF)-α and decreased insulin growth factor (IGF)-1β in the serum.
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030908
09AnimalAnimal study (in vivo)Efficacy outcome
In STZ-diabetic rats, CBL improved reduced serum IGF-1β compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL increased reduced serum IGF-1β compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
IncreaseSerum IGF-1beta
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
CBL improved serum TNF-α and IGF-1β, GLU and 5-HT as well as hampering oxidative biomarkers.
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetes was confirmed by hyperglycemia and elevated glycated haemoglobin (HbA1c%), which were associated by weight loss, elevated tumor necrosis factor (TNF)-α and decreased insulin growth factor (IGF)-1β in the serum.
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030909
10AnimalAnimal study (in vivo)Mechanism
In STZ-diabetic rats, CBL improved reduced hippocampal GLU compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL increased reduced hippocampal glutamate compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal glutamate
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
CBL improved serum TNF-α and IGF-1β, GLU and 5-HT as well as hampering oxidative biomarkers.
2 context sentences(design, population, supporting numbers)
Summary · context
Behavioral deficits were associated by decreased hippocampal glutamate (GLU), glycine, serotonin (5-HT) and dopamine.
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030910
11AnimalAnimal study (in vivo)Mechanism
In STZ-diabetic rats, CBL improved reduced hippocampal 5-HT compared with diabetic controls.
In plain wordsIn rats with diabetes, CBL increased reduced hippocampal serotonin compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal serotonin
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
CBL improved serum TNF-α and IGF-1β, GLU and 5-HT as well as hampering oxidative biomarkers.
2 context sentences(design, population, supporting numbers)
Summary · context
Behavioral deficits were associated by decreased hippocampal glutamate (GLU), glycine, serotonin (5-HT) and dopamine.
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030911
12AnimalAnimal study (in vivo)Mechanism
In STZ-diabetic rats, CBL hampered oxidative biomarkers compared with diabetic controls, without separate treatment results for each marker.
In plain wordsIn rats with diabetes, CBL improved oxidative biomarkers compared with diabetic controls.
Peptide
Cerebrolysin
Outcome
Direction not reportedOxidative biomarkers
Study
ratn: not reported in source
STZ-diabetic male adult Sprague Dawley rats
Comparator
STZ diabetic-control
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
CBL improved serum TNF-α and IGF-1β, GLU and 5-HT as well as hampering oxidative biomarkers.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end, male adult Sprague Dawley rats were divided into (i) vehicle- (ii) CBL- and (iii) STZ diabetic-control as well as (iv) STZ+CBL groups.
Show in the study text Report a problemFND-2384030912

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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