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Study · Not a test of the peptide alone · 2013

3 results

Ghrelin and nicotine stimulate equally the dopamine release in the rat amygdala.

Palotai M, Bagosi Z, Jászberényi M, Csabafi K, Dochnal R, Manczinger M, Telegdy G, Szabó G

Neurochemical research9 Jul 2013Cited by 23 (Europe PMC)

PMID23836294 (opens in a new tab)DOI10.1007/s11064-013-1105-1 (opens in a new tab)PepBankPUB-23836294
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01LabNot a test of GHRP-6 aloneEx vivo tissueMechanism

    In rat amygdalar slices, GHRP‑6 inhibited ghrelin-stimulated dopamine release following electrical stimulation.

    In plain wordsIn lab tests with rat brain slices, GHRP‑6 inhibited the increase in dopamine release from ghrelin stimulation.

    Peptide
    GHRP-6
    Outcome
    DecreaseGhrelin-stimulated dopamine release
    Study

    ratn: not reported in source

    Amygdalar slices
    Comparator
    Ghrelin stimulation without GHRP-6
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This effect was inhibited by both the selective GHS-R1A antagonist GHRP-6 and the selective nAchR antagonist mecamylamine.
    2 context sentences
    Summary · context
    Ghrelin increased significantly the dopamine release from the rat amygdala following electrical stimulation.
    Summary · context
    In the present study an in vitro superfusion of rat amygdalar slices was performed in order to investigate the direct action of ghrelin and nicotine on the amygdalar dopamine release.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneEx vivo tissueMechanism

    In rat amygdalar slices, GHRP‑6 did not antagonize nicotine-stimulated dopamine release.

    In plain wordsIn lab tests with rat brain slices, GHRP‑6 did not block the increase in dopamine release from nicotine stimulation.

    Peptide
    GHRP-6
    Outcome
    No significant changeNicotine-stimulated dopamine release
    Study

    ratn: not reported in source

    Amygdalar slices
    Comparator
    Nicotine stimulation without GHRP-6
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This effect was antagonized by mecamylamine, but not by GHRP-6.
    2 context sentences
    Summary · context
    Under the same conditions, nicotine also increased significantly the dopamine release from the rat amygdala.
    Summary · context
    In the present study an in vitro superfusion of rat amygdalar slices was performed in order to investigate the direct action of ghrelin and nicotine on the amygdalar dopamine release.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03LabNot a test of GHRP-6 aloneEx vivo tissueMechanism

    In rat amygdalar slices, GHRP‑6 partially reversed dopamine release stimulated by combined ghrelin and nicotine.

    In plain wordsIn lab tests with rat brain slices, GHRP‑6 partly reversed the increase in dopamine release from combined ghrelin and nicotine.

    Peptide
    GHRP-6
    Outcome
    DecreaseCombined ghrelin and nicotine-stimulated dopamine release
    Study

    ratn: not reported in source

    Amygdalar slices
    Comparator
    Ghrelin plus nicotine without GHRP-6
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This stimulatory effect was partially reversed by both GHRP-6 and mecamylamine.
    2 context sentences
    Summary · context
    Co-administration of ghrelin and nicotine induced a similar increase of amygdalar dopamine release.
    Summary · context
    In the present study an in vitro superfusion of rat amygdalar slices was performed in order to investigate the direct action of ghrelin and nicotine on the amygdalar dopamine release.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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