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Study · Not a test of the peptide alone · 2013

3 results

Ghrelin amplifies the nicotine-induced dopamine release in the rat striatum.

Palotai M, Bagosi Z, Jászberényi M, Csabafi K, Dochnal R, Manczinger M, Telegdy G, Szabó G

Neurochemistry international3 Jul 2013Cited by 26 (Europe PMC)

PMID23831084 (opens in a new tab)DOI10.1016/j.neuint.2013.06.014 (opens in a new tab)PepBankPUB-23831084
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01LabNot a test of GHRP-6 aloneEx vivo tissueMechanism

    In rat striatal slices, GHRP‑6 reversed ghrelin stimulation of dopamine release after electrical stimulation.

    In plain wordsIn lab tests with rat brain slices, GHRP‑6 reversed the increase in dopamine release from ghrelin stimulation.

    Peptide
    GHRP-6
    Outcome
    DecreaseGhrelin-stimulated dopamine release
    Study

    ratn: not reported in source

    Striatal slices
    Comparator
    Ghrelin stimulation without GHRP-6
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This stimulatory effect was reversed by both the selective nAchR antagonist mecamylamine and the selective GHS-R1A antagonist GHRP-6.
    2 context sentences
    Summary · context
    Ghrelin increased significantly the dopamine release from the rat striatum following electrical stimulation.
    Summary · context
    In the present study an in vitro superfusion of rat striatal slices was performed, in order to investigate the direct action of ghrelin on the striatal dopamine release and the interaction of ghrelin with nicotine through this neurotransmitter release.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneEx vivo tissueMechanism

    In rat striatal slices, GHRP‑6 did not antagonize nicotine-stimulated dopamine release.

    In plain wordsIn lab tests with rat brain slices, GHRP‑6 did not block the increase in dopamine release from nicotine stimulation.

    Peptide
    GHRP-6
    Outcome
    No significant changeNicotine-stimulated dopamine release
    Study

    ratn: not reported in source

    Striatal slices
    Comparator
    Nicotine stimulation without GHRP-6
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This stimulatory effect was antagonized by mecamylamine, but not by GHRP-6.
    2 context sentences
    Summary · context
    Nicotine also increased significantly the dopamine release under the same conditions.
    Summary · context
    In the present study an in vitro superfusion of rat striatal slices was performed, in order to investigate the direct action of ghrelin on the striatal dopamine release and the interaction of ghrelin with nicotine through this neurotransmitter release.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03LabNot a test of GHRP-6 aloneEx vivo tissueMechanism

    In rat striatal slices, GHRP‑6 partially inhibited ghrelin enhancement of nicotine-induced dopamine release.

    In plain wordsIn lab tests with rat brain slices, GHRP‑6 partly blocked the extra dopamine release from adding ghrelin to nicotine.

    Peptide
    GHRP-6
    Outcome
    DecreaseGhrelin enhancement of nicotine-stimulated dopamine release
    Study

    ratn: not reported in source

    Striatal slices
    Comparator
    Ghrelin plus nicotine without GHRP-6
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Ghrelin further stimulated the nicotine-induced dopamine release and this effect was abolished by mecamylamine and was partially inhibited by GHRP-6.
    1 context sentence
    Summary · context
    In the present study an in vitro superfusion of rat striatal slices was performed, in order to investigate the direct action of ghrelin on the striatal dopamine release and the interaction of ghrelin with nicotine through this neurotransmitter release.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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