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Study · In vitro (cells) · 2013

2 results

Human β defensin-3 induces chemokines from monocytes and macrophages: diminished activity in cells from HIV-infected persons.

Petrov V, Funderburg N, Weinberg A, Sieg S

Immunology1 Dec 2013Cited by 33 (Europe PMC)

PMID23829433 (opens in a new tab)DOI10.1111/imm.12148 (opens in a new tab)PepBankPUB-23829433
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human monocytes, LL‑37 induced a variety of chemokines, including MCP-1, Gro-α, MDC and MIP1β.

    In plain wordsIn cells, LL‑37 made human monocytes produce several chemokines, which are immune signalling proteins.

    Peptide
    LL-37
    Outcome
    IncreaseChemokine induction in monocytes
    Study

    humann: not reported in source

    Human monocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    each stimulant induced a variety of chemokines including monocyte chemoattractant protein 1 (MCP-1), Gro-α, macrophage-derived chemokine (MDC) and macrophage inflammatory protein 1β (MIP1β
    1 context sentence
    Summary · context
    We investigated the capacity of hBD-3 and, for comparison, Pam3CSK4 and LL-37 to induce co-stimulatory molecules and chemokine expression in monocytes.
  2. 02LabIn vitro (cells)Mechanism

    In human monocytes, LL‑37 did not significantly induce VEGF, unlike hBD-3 and Pam3CSK4.

    In plain wordsIn cells, LL‑37 did not clearly raise VEGF in human monocytes, while two other stimuli did.

    Peptide
    LL-37
    Outcome
    No significant changeVEGF induction in monocytes
    Study

    humann: not reported in source

    Human monocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    only hBD-3 and Pam3CSK4 significantly induced the angiogenesis factor, vascular endothelial growth factor (VEGF).
    1 context sentence
    Summary · context
    We investigated the capacity of hBD-3 and, for comparison, Pam3CSK4 and LL-37 to induce co-stimulatory molecules and chemokine expression in monocytes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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