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Study · Randomized controlled trial · n = 13 · 2013

4 results

Modulation of interpersonal trust in borderline personality disorder by intranasal oxytocin and childhood trauma.

Ebert A, Kolb M, Heller J, Edel MA, Roser P, Brüne M

Social neuroscience1 Jan 2013Cited by 70 (Europe PMC)

PMID23802121 (opens in a new tab)DOI10.1080/17470919.2013.807301 (opens in a new tab)PepBankPUB-23802121
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with borderline personality disorder, oxytocin reduced the money transferred in a trust game versus placebo.

    In plain wordsIn people with borderline personality disorder, oxytocin led to less money shared in a trust game than placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseMoney transferred in trust game, BPD patients
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Patients transferred less money in the oxytocin condition compared to placebo.
    1 context sentence
    Summary · context
    Thirteen BPD patients and thirteen healthy controls played a trust game after receiving oxytocin or placebo in a randomized, double-blind crossover design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy controls, oxytocin but not placebo was followed by more money transferred to attractive than to unattractive counterparts.

    In plain wordsIn healthy people, they shared more money with attractive partners only after oxytocin, not after placebo.

    Peptide
    Oxytocin
    Outcome
    MixedMoney transferred to attractive versus unattractive counterparts, healthy controls
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    While healthy controls transferred more money units (MUs) to attractive counterparts than to unattractive ones only after the administration of oxytocin
    1 context sentence
    Summary · context
    Thirteen BPD patients and thirteen healthy controls played a trust game after receiving oxytocin or placebo in a randomized, double-blind crossover design.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In patients with borderline personality disorder, the pattern of more money to attractive counterparts occurred in both the oxytocin and placebo conditions.

    In plain wordsIn people with borderline personality disorder, the same pattern of sharing appeared with oxytocin and with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeMoney transferred to attractive versus unattractive counterparts, BPD patients
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    BPD patients showed this pattern in both conditions.
    1 context sentence
    Summary · context
    Thirteen BPD patients and thirteen healthy controls played a trust game after receiving oxytocin or placebo in a randomized, double-blind crossover design.
  4. 04HumanRandomized controlled trialMechanism

    In patients with borderline personality disorder, emotional neglect in childhood correlated negatively with money transferred under oxytocin but not under placebo.

    In plain wordsIn people with borderline personality disorder, more childhood emotional neglect was linked to less money shared under oxytocin, not under placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseCorrelation of childhood emotional neglect with money transferred under oxytocin
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Emotional neglect during childhood negatively correlated with the amount of MUs transferred by patients under oxytocin, but not placebo.
    1 context sentence
    Summary · context
    Thirteen BPD patients and thirteen healthy controls played a trust game after receiving oxytocin or placebo in a randomized, double-blind crossover design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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