Practical application of cellular bioenergetics to the care of aged skin.

Osborne R, Carver RS, Mullins LA, Finlay DR

The British journal of dermatology1 Jul 2013Cited by 6 (Europe PMC)

PMID23786618DOI10.1111/bjd.12439PepBankPUB-23786618

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone13

In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

01LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In adult human fibroblasts, the niacinamide, Pal-KTTKS and Olivem complex increased procollagen-1, especially with dill extract.
In plain wordsIn cells, the mixture containing Pal-KTTKS increased procollagen-1, especially with dill extract.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseProcollagen-1
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661801
02LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In adult human fibroblasts, the niacinamide, Pal-KTTKS and Olivem complex increased NAD(+)/NADH, especially with dill extract.
In plain wordsIn cells, the mixture containing Pal-KTTKS increased NAD(+)/NADH, especially with dill extract.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseNAD(+)/NADH
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661802
03LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS increased COL1A1 mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS increased COL1A1 gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseCOL1A1 mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661803
04LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS increased COL3A1 mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS increased COL3A1 gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseCOL3A1 mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661804
05LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS increased COL5A1 mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS increased COL5A1 gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseCOL5A1 mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661805
06LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS increased COL14A1 mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS increased COL14A1 gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseCOL14A1 mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661806
07LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS increased ELN mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS increased ELN gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseELN mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661807
08LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS increased LOXL2 mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS increased LOXL2 gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseLOXL2 mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661808
09LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS increased SOD2 mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS increased SOD2 gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseSOD2 mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661809
10LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS increased NAMPT mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS increased NAMPT gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseNAMPT mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661810
11LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS increased TGFBR3 mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS increased TGFBR3 gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseTGFBR3 mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661811
12LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In one adult fibroblast strain, the complex containing Pal-KTTKS decreased MMP1 mRNA expression.
In plain wordsIn cells from one adult fibroblast strain, the mixture containing Pal-KTTKS decreased MMP1 gene activity.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
DecreaseMMP1 mRNA
Study
humann: not reported in source
Adult human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In one of the adult fibroblast strains evaluated, these changes in procollagen-1 and NAD(+)/NADH in response to the complex of bioactives were in parallel with increased expression of mRNA biomarkers related primarily to dermal matrix and basement membrane structure, including COL1A1, COL3A1, COL5A1…
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661812
13LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In adult fibroblasts, adding Lys'lastine V generally maintained or increased mRNA biomarker responses to the complex containing Pal-KTTKS.
In plain wordsIn cells, dill extract generally maintained or increased the mixture's gene activity responses compared with the mixture alone.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
MixedmRNA biomarker response with dill extract
Study
humann: not reported in source
Adult human skin fibroblasts
Comparator
Complex without Lys'lastine V
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In general, these mRNA biomarker effects were maintained or boosted by the addition of Lys'lastine V, particularly at 1%, and were similar to the fold changes in mRNA expression in neonatal compared with adult fibroblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
The levels of both procollagen-1 and NAD(+)/NADH were increased in the adult fibroblasts by treatment for 24 (NAD energy) or 48 h (procollagen-1) with a complex containing niacinamide, Pal-KTTKS peptide and an olive oil fatty acid derivative (Olivem(®)), especially in combination with a natural extr…
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-2378661813

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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