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Study · Animal study (in vivo) · rat · 2013

9 results

Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats.

Bentzen BH, Grunnet M, Hyveled-Nielsen L, Sundgreen C, Lassen JB, Hansen HH

Obesity (Silver Spring, Md.)1 May 2013Cited by 21 (Europe PMC)

PMID23784901 (opens in a new tab)DOI10.1002/oby.20122 (opens in a new tab)PepBankPUB-23784901
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, acute tesofensine reduced food intake in a dose-dependent manner.

    In plain wordsIn rats, acute tesofensine reduced food intake in a dose-dependent manner.

    Peptide
    Tesofensine
    Outcome
    DecreaseFood intake
    Study

    ratn: not reported in source

    Telemetrized conscious rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Acute administration of tesofensine caused a dose-dependent hypophagic effect as well as increased heart rate and blood pressure.
    1 context sentence
    Summary · context
    The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real-time food intake and cardiovascular telemetry monitoring system.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In rats, acute tesofensine increased heart rate.

    In plain wordsIn rats, acute tesofensine increased heart rate.

    Peptide
    Tesofensine
    Outcome
    IncreaseHeart rate
    Study

    ratn: not reported in source

    Telemetrized conscious rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Acute administration of tesofensine caused a dose-dependent hypophagic effect as well as increased heart rate and blood pressure.
    1 context sentence
    Summary · context
    The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real-time food intake and cardiovascular telemetry monitoring system.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In rats, acute tesofensine increased blood pressure.

    In plain wordsIn rats, acute tesofensine increased blood pressure.

    Peptide
    Tesofensine
    Outcome
    IncreaseBlood pressure
    Study

    ratn: not reported in source

    Telemetrized conscious rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Acute administration of tesofensine caused a dose-dependent hypophagic effect as well as increased heart rate and blood pressure.
    1 context sentence
    Summary · context
    The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real-time food intake and cardiovascular telemetry monitoring system.

Studies that did not test the peptide alone6

In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Tesofensine.

  1. 04AnimalNot a test of Tesofensine aloneAnimal study (in vivo)Mechanism

    In rats, metoprolol prevented the heart rate effects of tesofensine.

    In plain wordsIn rats, metoprolol prevented the heart rate effects of tesofensine.

    Peptide
    Tesofensine
    Outcome
    DecreaseHeart rate with metoprolol
    Study

    ratn: not reported in source

    Telemetrized conscious rats
    Comparator
    Tesofensine alone
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Interestingly, combined treatment with metoprolol (b1 adrenoceptor blocker, 10-20 mg/kg, p.o.) fully prevented the cardiovascular sympathetic effects of tesofensine while leaving the robust inhibitory efficacy on food intake unaffected.
    1 context sentence
    Summary · context
    The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real-time food intake and cardiovascular telemetry monitoring system.

    In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tesofensine.

  2. 05AnimalNot a test of Tesofensine aloneAnimal study (in vivo)Mechanism

    In rats, metoprolol prevented the blood pressure effects of tesofensine.

    In plain wordsIn rats, metoprolol prevented the blood pressure effects of tesofensine.

    Peptide
    Tesofensine
    Outcome
    DecreaseBlood pressure with metoprolol
    Study

    ratn: not reported in source

    Telemetrized conscious rats
    Comparator
    Tesofensine alone
    Outcome group
    Blood pressure · Cardiovascular

    Source sentences

    Summary
    Interestingly, combined treatment with metoprolol (b1 adrenoceptor blocker, 10-20 mg/kg, p.o.) fully prevented the cardiovascular sympathetic effects of tesofensine while leaving the robust inhibitory efficacy on food intake unaffected.
    1 context sentence
    Summary · context
    The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real-time food intake and cardiovascular telemetry monitoring system.

    In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tesofensine.

  3. 06AnimalNot a test of Tesofensine aloneAnimal study (in vivo)Mechanism

    In rats, metoprolol did not alter tesofensine-induced food intake suppression.

    In plain wordsIn rats, metoprolol did not alter tesofensine-induced food intake suppression.

    Peptide
    Tesofensine
    Outcome
    No significant changeFood intake with metoprolol
    Study

    ratn: not reported in source

    Telemetrized conscious rats
    Comparator
    Tesofensine alone
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Interestingly, combined treatment with metoprolol (b1 adrenoceptor blocker, 10-20 mg/kg, p.o.) fully prevented the cardiovascular sympathetic effects of tesofensine while leaving the robust inhibitory efficacy on food intake unaffected.
    1 context sentence
    Summary · context
    The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real-time food intake and cardiovascular telemetry monitoring system.

    In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tesofensine.

  4. 07AnimalNot a test of Tesofensine aloneAnimal study (in vivo)Mechanism

    In rats, telmisartan did not interfere with the anti-obesity effects of tesofensine.

    In plain wordsIn rats, telmisartan did not interfere with the anti-obesity effects of tesofensine.

    Peptide
    Tesofensine
    Outcome
    No significant changeAnti-obesity effect with telmisartan
    Study

    ratn: not reported in source

    Telemetrized conscious rats
    Comparator
    Tesofensine alone
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Similarly, the angiotensin AT1 receptor antagonist telmisartan (1.0-3.0 mg/kg, p.o.) did not interfere with the anti-obesity effects of tesofensine
    1 context sentence
    Summary · context
    The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real-time food intake and cardiovascular telemetry monitoring system.

    In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tesofensine.

  5. 08AnimalNot a test of Tesofensine aloneAnimal study (in vivo)Mechanism

    In rats, telmisartan partially reversed the systolic blood pressure increase induced by tesofensine.

    In plain wordsIn rats, telmisartan partially reversed the systolic blood pressure increase induced by tesofensine.

    Peptide
    Tesofensine
    Outcome
    DecreaseSystolic blood pressure with telmisartan
    Study

    ratn: not reported in source

    Telemetrized conscious rats
    Comparator
    Tesofensine alone
    Outcome group
    Blood pressure · Cardiovascular

    Source sentences

    Summary
    however, telmisartan only partially reversed the increase in systolic blood pressure and had no effect on the elevated heart rate induced by tesofensine.
    1 context sentence
    Summary · context
    The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real-time food intake and cardiovascular telemetry monitoring system.

    In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tesofensine.

  6. 09AnimalNot a test of Tesofensine aloneAnimal study (in vivo)Mechanism

    In rats, telmisartan did not affect the elevated heart rate induced by tesofensine.

    In plain wordsIn rats, telmisartan did not affect the elevated heart rate induced by tesofensine.

    Peptide
    Tesofensine
    Outcome
    No significant changeHeart rate with telmisartan
    Study

    ratn: not reported in source

    Telemetrized conscious rats
    Comparator
    Tesofensine alone
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    however, telmisartan only partially reversed the increase in systolic blood pressure and had no effect on the elevated heart rate induced by tesofensine.
    1 context sentence
    Summary · context
    The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real-time food intake and cardiovascular telemetry monitoring system.

    In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tesofensine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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