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Study · Measured the body's own peptide · 2013

4 results

Salivary concentration of free LL-37 in edentulism, chronic periodontitis and healthy periodontium.

Davidopoulou S, Diza E, Sakellari D, Menexes G, Kalfas S

Archives of oral biology8 Feb 2013Cited by 27 (Europe PMC)

PMID23778112 (opens in a new tab)DOI10.1016/j.archoralbio.2013.01.003 (opens in a new tab)PepBankPUB-23778112
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    Median salivary free LL‑37 was 30.5 ng/ml in healthy, 22.5 ng/ml in chronic periodontitis and 1.8 ng/ml in edentulous subjects.

    In plain wordsThe body's own free LL‑37 in saliva was highest in healthy people, slightly lower with gum disease, and lowest in people without teeth.

    Peptide
    LL-37
    Outcome
    Not applicableMedian salivary free LL-37 by group
    Study

    n = 154

    Outcome group
    Inflammation markers · Immune and inflammation

    Measurements

    median free LL-37
    30.5 ng/ml
    healthy
    median free LL-37
    22.5 ng/ml
    chronic periodontitis
    median free LL-37
    1.8 ng/ml
    edentulous

    Source sentences

    Summary
    The median salivary concentrations of free LL-37 were 30.5, 22.5, and 1.8ng/ml for the healthy, the chronic periodontitis and the edentulous group, respectively.
    1 context sentence
    Summary · context
    Unstimulated whole saliva was sampled from 154 subjects (76 periodontally healthy, 20 edentulous, and 58 subjects with chronic periodontitis).

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Salivary free LL‑37 concentrations were significantly lower in edentulous subjects than in healthy and chronic periodontitis subjects.

    In plain wordsPeople without teeth had much lower levels of the body's own LL‑37 in saliva than people with teeth.

    Peptide
    LL-37
    Outcome
    DecreaseSalivary free LL-37 in edentulous versus other groups
    Study

    n = 154

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    The differences in concentration between the edentulous and the others were statistically significant (Mann-Whitney test, p<0.001).
    2 context sentences
    Summary · context
    The present findings show that edentulism correlates with a substantial decrease in salivary levels of free LL-37, thus indicating the considerable contribution of the gingival tissues in the secretion of the peptide in the oral environment.
    Summary · context
    Unstimulated whole saliva was sampled from 154 subjects (76 periodontally healthy, 20 edentulous, and 58 subjects with chronic periodontitis).

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    Intra-subject variation in salivary LL‑37 was wider in healthy and chronic periodontitis subjects than in edentulous subjects.

    In plain wordsThe body's own LL‑37 in saliva varied more between samples in people with teeth than in people without teeth.

    Peptide
    LL-37
    Outcome
    Not applicableIntra-subject variation in salivary LL-37
    Study

    n = 154

    Outcome group
    Inflammation markers · Immune and inflammation

    Measurements

    range, healthy
    0.75 to 285 ng/ml
    healthy
    range, chronic periodontitis
    1 to 207 ng/ml
    chronic periodontitis
    range, edentulous
    0.15 to 4.4 ng/ml
    edentulous

    Source sentences

    Summary
    The intra-subject variation in LL-37 concentration was wider for the healthy (range 0.75-285ng/ml) and chronic periodontitis patients (range 1-207ng/ml) than for the edentulous subjects (range 0.15-4.4ng/ml).
    1 context sentence
    Summary · context
    Unstimulated whole saliva was sampled from 154 subjects (76 periodontally healthy, 20 edentulous, and 58 subjects with chronic periodontitis).

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In periodontally healthy subjects, women had significantly higher salivary LL‑37 concentrations than men.

    In plain wordsAmong healthy people, women had higher levels of the body's own LL‑37 in saliva than men.

    Peptide
    LL-37
    Outcome
    IncreaseSalivary free LL-37 in women versus men
    Study

    n = 76

    Comparator
    Men
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    In the healthy subjects, women displayed significantly higher peptide concentrations compared to men (Mann-Whitney test, p<0.05).
    1 context sentence
    Summary · context
    Unstimulated whole saliva was sampled from 154 subjects (76 periodontally healthy, 20 edentulous, and 58 subjects with chronic periodontitis).

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase not statedNCT04404335

The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.

Universidad Rey Juan Carlosn = 6017 May 2021 to 15 Jul 2022

Periodontal Diseases · Periodontitis

Trial pageClinicalTrials.govUpdated 30 Sept 2022

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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