Skip to content

Study · Randomized controlled trial · n = 100 · 2013

2 results

Stress-induced negative mood moderates the relation between oxytocin administration and trust: evidence for the tend-and-befriend response to stress?

Cardoso C, Ellenbogen MA, Serravalle L, Linnen AM

Psychoneuroendocrinology12 Jun 2013Cited by 40 (Europe PMC)

PMID23768973 (opens in a new tab)DOI10.1016/j.psyneuen.2013.05.006 (opens in a new tab)PepBankPUB-23768973
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In students with a negative mood response after social rejection, intranasal oxytocin increased self-perceived trust versus placebo.

    In plain wordsIn students who felt low after social rejection, oxytocin raised self-perceived trust more than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseSelf-perceived trust after social rejection, negative mood responders
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Multiple regression and simple slope analysis revealed that oxytocin administration increased self-perceived trust relative to placebo in participants reporting a negative mood response following social rejection [b=4.245, t(96)=3.10, p=.003]
    1 context sentence
    Summary · context
    In a double-blind experiment, 100 students (50 ♀) were subject to a live social rejection paradigm following random assignment to either a 24 IU intranasal oxytocin or placebo administration.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In students whose mood was euthymic after social rejection, oxytocin did not increase self-perceived trust versus placebo.

    In plain wordsIn students whose mood stayed normal after social rejection, oxytocin did not raise trust more than placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSelf-perceived trust after social rejection, euthymic participants
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    but not in those whose mood state was euthymic.
    1 context sentence
    Summary · context
    In a double-blind experiment, 100 students (50 ♀) were subject to a live social rejection paradigm following random assignment to either a 24 IU intranasal oxytocin or placebo administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.