Effect of intermittent PTH (1-34) on posterolateral spinal fusion with iliac crest bone graft in an ovariectomized rat model.

Qiu Z, Wei L, Liu J, Sochacki KR, Liu X, Bishop C, Ebraheim M, Yang H

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA12 Jun 2013Cited by 37 (Europe PMC)

PMID23756875DOI10.1007/s00198-013-2385-7PepBankPUB-23756875

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, PTH increased spinal fusion rates compared with saline at both assessments.
In plain wordsIn rats, PTH increased spinal fusion rates compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSpinal fusion rate
Study
ratn = 18
ovariectomized Sprague-Dawley rats after posterolateral spinal fusion
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 μg/kg/day · subcutaneous · 4 and 6 weeksAs given in this study (rat).
Source sentences
Summary
The PTH group had a significantly higher fusion rate and X-ray fusion score than the control group at 4 and 6 weeks (p < 0.05).
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty-six 10-week-old Sprague-Dawley rats were ovariectomized and underwent bilateral posterolateral L4-L5 spinal fusion with autologous iliac bone graft 6 weeks later.
Summary · context
The experimental (PTH) group (18 rats) received daily subcutaneously administered injections of PTH (1-34) at 30 μg/kg/day starting on the day of operation.
Summary · context
The control group (18 rats) received a subcutaneously administered injection of normal saline of the same volume.
Summary · context
Nine rats from each group were sacrificed at 4 and 6 weeks.
Report a problemFND-2375687501
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, PTH increased X-ray fusion scores compared with saline at both assessments.
In plain wordsIn rats, PTH increased X-ray spinal fusion scores compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseX-ray fusion score
Study
ratn = 18
ovariectomized Sprague-Dawley rats after posterolateral spinal fusion
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 μg/kg/day · subcutaneous · 4 and 6 weeksAs given in this study (rat).
Source sentences
Summary
The PTH group had a significantly higher fusion rate and X-ray fusion score than the control group at 4 and 6 weeks (p < 0.05).
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty-six 10-week-old Sprague-Dawley rats were ovariectomized and underwent bilateral posterolateral L4-L5 spinal fusion with autologous iliac bone graft 6 weeks later.
Summary · context
The experimental (PTH) group (18 rats) received daily subcutaneously administered injections of PTH (1-34) at 30 μg/kg/day starting on the day of operation.
Summary · context
The control group (18 rats) received a subcutaneously administered injection of normal saline of the same volume.
Summary · context
Nine rats from each group were sacrificed at 4 and 6 weeks.
Report a problemFND-2375687502
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, PTH increased fusion bone volume compared with saline at both assessments.
In plain wordsIn rats, PTH increased spinal fusion bone volume compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFusion bone volume
Study
ratn = 18
ovariectomized Sprague-Dawley rats after posterolateral spinal fusion
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 μg/kg/day · subcutaneous · 4 and 6 weeksAs given in this study (rat).
Source sentences
Summary
μ-CT and histological analysis showed that the fusion bone volume and cortical thickness for the PTH group were significantly higher than those for the control group at 4 and 6 weeks (p < 0.05).
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty-six 10-week-old Sprague-Dawley rats were ovariectomized and underwent bilateral posterolateral L4-L5 spinal fusion with autologous iliac bone graft 6 weeks later.
Summary · context
The experimental (PTH) group (18 rats) received daily subcutaneously administered injections of PTH (1-34) at 30 μg/kg/day starting on the day of operation.
Summary · context
The control group (18 rats) received a subcutaneously administered injection of normal saline of the same volume.
Summary · context
Nine rats from each group were sacrificed at 4 and 6 weeks.
Report a problemFND-2375687503
04AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, PTH increased fusion cortical thickness compared with saline at both assessments.
In plain wordsIn rats, PTH increased cortical bone thickness at spinal fusion sites compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFusion cortical thickness
Study
ratn = 18
ovariectomized Sprague-Dawley rats after posterolateral spinal fusion
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 μg/kg/day · subcutaneous · 4 and 6 weeksAs given in this study (rat).
Source sentences
Summary
μ-CT and histological analysis showed that the fusion bone volume and cortical thickness for the PTH group were significantly higher than those for the control group at 4 and 6 weeks (p < 0.05).
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty-six 10-week-old Sprague-Dawley rats were ovariectomized and underwent bilateral posterolateral L4-L5 spinal fusion with autologous iliac bone graft 6 weeks later.
Summary · context
The experimental (PTH) group (18 rats) received daily subcutaneously administered injections of PTH (1-34) at 30 μg/kg/day starting on the day of operation.
Summary · context
The control group (18 rats) received a subcutaneously administered injection of normal saline of the same volume.
Summary · context
Nine rats from each group were sacrificed at 4 and 6 weeks.
Report a problemFND-2375687504
05AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, PTH increased serum osteocalcin compared with saline at both assessments.
In plain wordsIn rats, PTH increased blood osteocalcin compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum osteocalcin
Study
ratn = 18
ovariectomized Sprague-Dawley rats after posterolateral spinal fusion
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 μg/kg/day · subcutaneous · 4 and 6 weeksAs given in this study (rat).
Source sentences
Summary
The serum osteocalcin was significantly higher in the PTH group at 4 and 6 weeks, and levels of N-terminal peptide of type I collagen were significantly higher at 4 weeks (p < 0.05).
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty-six 10-week-old Sprague-Dawley rats were ovariectomized and underwent bilateral posterolateral L4-L5 spinal fusion with autologous iliac bone graft 6 weeks later.
Summary · context
The experimental (PTH) group (18 rats) received daily subcutaneously administered injections of PTH (1-34) at 30 μg/kg/day starting on the day of operation.
Summary · context
The control group (18 rats) received a subcutaneously administered injection of normal saline of the same volume.
Summary · context
Nine rats from each group were sacrificed at 4 and 6 weeks.
Report a problemFND-2375687505
06AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, PTH increased N-terminal peptide of type I collagen compared with saline at 4 weeks.
In plain wordsIn rats, PTH increased a collagen marker compared with saline at 4 weeks.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseN-terminal peptide of type I collagen
Study
ratn = 18
ovariectomized Sprague-Dawley rats after posterolateral spinal fusion
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 μg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).
Source sentences
Summary
The serum osteocalcin was significantly higher in the PTH group at 4 and 6 weeks, and levels of N-terminal peptide of type I collagen were significantly higher at 4 weeks (p < 0.05).
4 context sentences(design, population, supporting numbers)
Summary · context
Thirty-six 10-week-old Sprague-Dawley rats were ovariectomized and underwent bilateral posterolateral L4-L5 spinal fusion with autologous iliac bone graft 6 weeks later.
Summary · context
The experimental (PTH) group (18 rats) received daily subcutaneously administered injections of PTH (1-34) at 30 μg/kg/day starting on the day of operation.
Summary · context
The control group (18 rats) received a subcutaneously administered injection of normal saline of the same volume.
Summary · context
Nine rats from each group were sacrificed at 4 and 6 weeks.
Report a problemFND-2375687506

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Version history

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Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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