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Study · Measured the body's own peptide · 2013

4 results

IGF-IEc expression is associated with advanced clinical and pathological stage of prostate cancer.

Savvani A, Petraki C, Msaouel P, Diamanti E, Xoxakos I, Koutsilieris M

Anticancer research1 Jun 2013Cited by 16 (Europe PMC)

PMID23749893 (opens in a new tab)PepBankPUB-23749893
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In prostate specimens, normal epithelium showed negative or mild IGF-IEc expression, whereas prostate cancer showed mild to strong expression.

    In plain wordsIn prostate tissue, the body's own IGF-IEc (MGF) was low in normal cells and mild to strong in cancer cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-IEc expression, normal prostate versus prostate cancer
    Study

    n = 83

    Comparator
    Normal prostate epithelium
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Normal prostate epithelium was negative or demonstrated mild IGF-IEc cytoplasmic expression whereas prostate cancer exhibited mild to strong cytoplasmic immunoexpression.
    1 context sentence
    Summary · context
    Formalin-fixed and paraffin-embedded prostate cancer surgical specimens from 83 patients were assessed by immunohistochemistry for IGF-IEc expression.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In prostate cancer specimens, IGF-IEc expression was significantly lower in localized tumors than in locally advanced tumors.

    In plain wordsIn prostate cancer tissue, the body's own IGF-IEc (MGF) was lower in early tumors than in advanced tumors.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-IEc expression, localized versus locally advanced prostate cancer
    Study

    n = 83

    Comparator
    Localized (stage up to IIb) tumors
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    The mean IGF-1Ec expression, was significantly lower (p=0.004) in localized (stage ≤ IIb) prostate cancer, compared to locally advanced tumors (stage ≥ III).
    1 context sentence
    Summary · context
    Formalin-fixed and paraffin-embedded prostate cancer surgical specimens from 83 patients were assessed by immunohistochemistry for IGF-IEc expression.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In prostate cancer specimens, only one of 83 samples was completely negative for IGF-IEc expression.

    In plain wordsIn prostate cancer tissue, almost all samples showed the body's own IGF-IEc (MGF); only one of 83 did not.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableProstate cancer samples negative for IGF-IEc
    Study

    n = 83

    Outcome group
    Tumor growth · Cancer

    Measurements

    Negative samples
    1.2%
    prostate cancer samples

    Source sentences

    Summary
    Only one out of 83 (1.2%) prostate cancer samples was completely negative for IGF-IEc.
    1 context sentence
    Summary · context
    Formalin-fixed and paraffin-embedded prostate cancer surgical specimens from 83 patients were assessed by immunohistochemistry for IGF-IEc expression.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In prostate cancer specimens, IGF-IEc expression showed a weak positive correlation with Gleason score.

    In plain wordsIn prostate cancer tissue, higher natural IGF-IEc (MGF) levels were weakly linked to a higher Gleason score.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-IEc expression and Gleason score correlation
    Study

    n = 83

    Outcome group
    Tumor growth · Cancer

    Measurements

    Correlation coefficient r
    0.247
    IGF-IEc expression vs Gleason score

    Source sentences

    Summary
    A weak-positive correlation was also observed between IGF-IEc expression levels and Gleason score (r=0.247; p=0.024).
    1 context sentence
    Summary · context
    Formalin-fixed and paraffin-embedded prostate cancer surgical specimens from 83 patients were assessed by immunohistochemistry for IGF-IEc expression.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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