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Study · Animal study (in vivo) · rat · 2013

4 results

Effects of topical copper tripeptide complex on wound healing in an irradiated rat model.

Parker NP, Ardeshirpour F, Schmechel SC, Lassig AA

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery6 Jun 2013

PMID23744835 (opens in a new tab)DOI10.1177/0194599813492644 (opens in a new tab)PepBankPUB-23744835
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rat dorsal flaps, topical GHK‑Cu gel did not significantly change mean ischemic area compared with control at the P < .01 threshold.

    In plain wordsIn irradiated rats, GHK‑Cu gel did not significantly change the area of poorly supplied skin compared with control ointment.

    Peptide
    GHK-Cu
    Outcome
    No significant changeFlap ischemic area
    Study

    ratn = 23

    irradiated dorsal flap
    Comparator
    Aquaphilic ointment (control)
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical · 10 daysAs given in this study (rat).

    Measurements

    Mean ischemic area
    5 cm2
    GHK-Cu gel
    Mean ischemic area
    3.8 cm2
    control

    Source sentences

    Summary
    By digital analysis of clinical images, 13 test and 10 control animals showed mean ischemic areas of 5.0 cm(2) (SD = 0.9) for tests and 3.8 cm(2) (SD = 1.1; P = .011) for controls.
    4 context sentences
    Summary · context
    Animals were euthanized, digital images of flaps were taken, and harvested tissues were immunohistochemically stained for a vascular endothelium marker, caveolin-1, and vascular endothelial growth factor (VEGF).
    Summary · context
    After dorsal irradiation and a 28-day recovery period, 2 × 8 cm cranially based dorsal flaps were created in Sprague-Dawley rats.
    Summary · context
    Twice daily GHK-Cu gel (test) or aquaphilic ointment (control) was applied for 10 days.
    Summary · context
    Unpaired t-tests were used for statistical analyses; significance of P < .01 accounted for multiple comparisons.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rat dorsal flaps, topical GHK‑Cu gel did not significantly change the number of caveolin-1-stained blood vessels compared with control.

    In plain wordsIn irradiated rats, GHK‑Cu gel did not change the number of blood vessels compared with control ointment.

    Peptide
    GHK-Cu
    Outcome
    No significant changeCaveolin-1-stained vessel number
    Study

    ratn: not reported in source

    irradiated dorsal flap
    Comparator
    Aquaphilic ointment (control)
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical · 10 daysAs given in this study (rat).

    Measurements

    Mean vessel count
    209 vessels
    GHK-Cu gel
    Mean vessel count
    207.4 vessels
    control

    Source sentences

    Summary
    Caveolin-1 analyses showed a mean of 209.0 vessels (SD = 111.1) and a mean vessel luminal area of 525.7 um(2) (SD = 191.0) in tests and 207.4 vessels (SD = 109.4; P = .973) and 422.8 um(2) (SD = 109.7; P = .118) in controls.
    3 context sentences
    Summary · context
    After dorsal irradiation and a 28-day recovery period, 2 × 8 cm cranially based dorsal flaps were created in Sprague-Dawley rats.
    Summary · context
    Twice daily GHK-Cu gel (test) or aquaphilic ointment (control) was applied for 10 days.
    Summary · context
    Unpaired t-tests were used for statistical analyses; significance of P < .01 accounted for multiple comparisons.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rat dorsal flaps, topical GHK‑Cu gel did not significantly change blood vessel luminal area compared with control.

    In plain wordsIn irradiated rats, GHK‑Cu gel did not change blood vessel opening size compared with control ointment.

    Peptide
    GHK-Cu
    Outcome
    No significant changeCaveolin-1-stained vessel luminal area
    Study

    ratn: not reported in source

    irradiated dorsal flap
    Comparator
    Aquaphilic ointment (control)
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical · 10 daysAs given in this study (rat).

    Measurements

    Mean vessel luminal area
    525.7 um2
    GHK-Cu gel
    Mean vessel luminal area
    422.8 um2
    control

    Source sentences

    Summary
    Caveolin-1 analyses showed a mean of 209.0 vessels (SD = 111.1) and a mean vessel luminal area of 525.7 um(2) (SD = 191.0) in tests and 207.4 vessels (SD = 109.4; P = .973) and 422.8 um(2) (SD = 109.7; P = .118) in controls.
    3 context sentences
    Summary · context
    After dorsal irradiation and a 28-day recovery period, 2 × 8 cm cranially based dorsal flaps were created in Sprague-Dawley rats.
    Summary · context
    Twice daily GHK-Cu gel (test) or aquaphilic ointment (control) was applied for 10 days.
    Summary · context
    Unpaired t-tests were used for statistical analyses; significance of P < .01 accounted for multiple comparisons.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated rat dorsal flaps, topical GHK‑Cu gel did not significantly change VEGF expression compared with control.

    In plain wordsIn irradiated rats, GHK‑Cu gel did not change VEGF levels in healing tissue compared with control ointment.

    Peptide
    GHK-Cu
    Outcome
    No significant changeVEGF expression in fibroblasts
    Study

    ratn: not reported in source

    irradiated dorsal flap
    Comparator
    Aquaphilic ointment (control)
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical · 10 daysAs given in this study (rat).

    Measurements

    Mean VEGF intensity score
    0.34
    GHK-Cu gel
    Mean VEGF intensity score
    0.54
    control

    Source sentences

    Summary
    VEGF quantified as the percentage of pixels exceeding a colorimetric threshold, with higher fractions of positive pixels indicating more intense staining, showed a mean intensity score of 0.34 (SD = 0.19) in tests and 0.54 (SD = 0.41; P = .169) in controls.
    3 context sentences
    Summary · context
    After dorsal irradiation and a 28-day recovery period, 2 × 8 cm cranially based dorsal flaps were created in Sprague-Dawley rats.
    Summary · context
    Twice daily GHK-Cu gel (test) or aquaphilic ointment (control) was applied for 10 days.
    Summary · context
    Unpaired t-tests were used for statistical analyses; significance of P < .01 accounted for multiple comparisons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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