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Study · Non-randomized trial · n = 60 · 2013

13 results

[Developmental dysphasia in children: perspectives of neurotrophic therapy].

Zavadenko NN, Kozlova EV

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2013Cited by 1 (Europe PMC)

PMID23739513 (opens in a new tab)PepBankPUB-23739513
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. 13 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, active vocabulary increased by a factor of 3.5 with cerebrolysin versus 1.5 in controls.

    In plain wordsIn children with developmental dysphasia, vocabulary increased more with cerebrolysin than without pharmacotherapy.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseActive vocabulary
    Study

    n = 60

    Comparator
    No pharmacotherapy
    Outcome group
    Speech and language · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Measurements

    Vocabulary increase factor
    3.5
    cerebrolysin
    Control increase factor
    1.5
    control

    Source sentences

    Summary
    The active vocabulary increased by a factor of 3.5 and phrases number in colloquial speech by a factor of 5, versus 1.5 in the control group.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  2. 02HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, colloquial phrase count increased by a factor of 5 with cerebrolysin versus 1.5 in controls.

    In plain wordsIn children with developmental dysphasia, phrase count increased more with cerebrolysin than without pharmacotherapy.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseColloquial phrase count
    Study

    n = 60

    Comparator
    No pharmacotherapy
    Outcome group
    Speech and language · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Measurements

    Phrase increase factor
    5
    cerebrolysin
    Control increase factor
    1.5
    control

    Source sentences

    Summary
    The active vocabulary increased by a factor of 3.5 and phrases number in colloquial speech by a factor of 5, versus 1.5 in the control group.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  3. 03HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, cerebrolysin significantly improved expressive speech after treatment.

    In plain wordsIn children with developmental dysphasia, expressive speech improved after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseExpressive speech
    Study

    n = 30

    Outcome group
    Speech and language · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    A significant improvement of expressive, impressive speech and speech attention was observed in group 1 after the treatment.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  4. 04HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, cerebrolysin significantly improved impressive speech after treatment.

    In plain wordsIn children with developmental dysphasia, impressive speech improved after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseImpressive speech
    Study

    n = 30

    Outcome group
    Speech and language · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    A significant improvement of expressive, impressive speech and speech attention was observed in group 1 after the treatment.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  5. 05HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, cerebrolysin significantly improved speech attention after treatment.

    In plain wordsIn children with developmental dysphasia, speech attention improved after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSpeech attention
    Study

    n = 30

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    A significant improvement of expressive, impressive speech and speech attention was observed in group 1 after the treatment.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  6. 06HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, parents reported decreased psychasthenic problems after cerebrolysin treatment.

    In plain wordsIn children with developmental dysphasia, parents reported fewer psychasthenic problems after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePsychasthenic problems
    Study

    n = 30

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    According to parents' questionnaires, the treatment resulted in the decrease of psychasthenic, psychosomatic problems, motor clumsiness and hyperactivity along with the improvement of attention, emotional control and behavioral measures.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  7. 07HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, parents reported decreased psychosomatic problems after cerebrolysin treatment.

    In plain wordsIn children with developmental dysphasia, parents reported fewer psychosomatic problems after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePsychosomatic problems
    Study

    n = 30

    Outcome group
    Psychiatric symptoms · Whole body
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    According to parents' questionnaires, the treatment resulted in the decrease of psychasthenic, psychosomatic problems, motor clumsiness and hyperactivity along with the improvement of attention, emotional control and behavioral measures.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  8. 08HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, parents reported decreased motor clumsiness after cerebrolysin treatment.

    In plain wordsIn children with developmental dysphasia, parents reported less motor clumsiness after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMotor clumsiness
    Study

    n = 30

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    According to parents' questionnaires, the treatment resulted in the decrease of psychasthenic, psychosomatic problems, motor clumsiness and hyperactivity along with the improvement of attention, emotional control and behavioral measures.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  9. 09HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, parents reported decreased hyperactivity after cerebrolysin treatment.

    In plain wordsIn children with developmental dysphasia, parents reported less hyperactivity after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHyperactivity
    Study

    n = 30

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    According to parents' questionnaires, the treatment resulted in the decrease of psychasthenic, psychosomatic problems, motor clumsiness and hyperactivity along with the improvement of attention, emotional control and behavioral measures.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  10. 10HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, parents reported improved attention after cerebrolysin treatment.

    In plain wordsIn children with developmental dysphasia, parents reported better attention after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAttention
    Study

    n = 30

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    According to parents' questionnaires, the treatment resulted in the decrease of psychasthenic, psychosomatic problems, motor clumsiness and hyperactivity along with the improvement of attention, emotional control and behavioral measures.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  11. 11HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, parents reported improved emotional control after cerebrolysin treatment.

    In plain wordsIn children with developmental dysphasia, parents reported better emotional control after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseEmotional control
    Study

    n = 30

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    According to parents' questionnaires, the treatment resulted in the decrease of psychasthenic, psychosomatic problems, motor clumsiness and hyperactivity along with the improvement of attention, emotional control and behavioral measures.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  12. 12HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, parents reported improved behavioral measures after cerebrolysin treatment.

    In plain wordsIn children with developmental dysphasia, parents reported better behavior after cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBehavioral measures
    Study

    n = 30

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    According to parents' questionnaires, the treatment resulted in the decrease of psychasthenic, psychosomatic problems, motor clumsiness and hyperactivity along with the improvement of attention, emotional control and behavioral measures.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.
  13. 13HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, motor milestone assessments showed improved motor development with cerebrolysin.

    In plain wordsIn children with developmental dysphasia, motor assessments showed improved development with cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMotor development
    Study

    n = 30

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    0.1 ml/kg on each other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    The positive effect of cerebrolysin on the motor development was demonstrated by the assessment of motor milestones.
    3 context sentences
    Summary · context
    To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years.
    Summary · context
    Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months.
    Summary · context
    Group 2 (controls, 30 patients) did not receive pharmacotherapy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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